Substituted pyridine herbicides

ABSTRACT

This invention relates to certain herbicidal pyridine compounds, agriculturally suitable compositions and a method of use of herbicidal pyridine compounds.

This application is a continuation filed under 35 USC 371 of PCT/US92/04644, which is a continuation-in-part of Ser. No. 07/713,909, filed Jun. 12, 1991, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to agriculturally suitable compositions of certain herbicidal pyridine compounds and a method for their use as selective preemergent or postemergent herbicides for controlling the growth of undesired vegetation in crops such as rice.

New compounds effective for controlling the growth of undesired vegetation are in constant demand. In the most common situation, such compounds are sought to selectively control the growth of weeds in useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. There are many products commercially available for these purposes, but the search continues for products which are more effective, less costly and environmentally safe.

U.S. Pat. No. 3,495,969 discloses compounds of the following structure as herbicides: ##STR1## wherein

R₁ and R₂ are H, C₁ -C₈ alkyl, C₃ -C₆ cycloalkyl, etc.;

X is H, CN, OH, halogen, sulfoxide, sulfonic acid, sulfone, --CON(R₂)₂, carboxyl, haloalkyl, C₁ -C₆ alkyl, haloalkoxy, alkoxy, aryl, aryloxy, haloaryloxy, carbalkoxy, carbonyl, thiol, thioalkoxy, alkylthio, arylthio and halarylthio;

m is 1 or 2;

n is at least 1;

q is 0 or 1;

r is 0, 1 or 2.

SUMMARY OF THE INVENTION

This invention is directed to an agriculturally suitable composition for controlling the growth of undesired vegetation in a crop comprising an effective amount of a compound of Formula I ##STR2## wherein

R¹ is Cl, Br, I, OCH₃, OCHF₂ or OCF₃ ;

R² is CN, CO₂ R⁴, CHO, C(X)NR¹⁷ R¹⁸, C(S)OR⁶, C.tbd.CH, CHR¹⁹ OR²⁰, CH═NOR⁷ or CH═CR²¹ R²² ;

R³ is n-propyl; C₄ -C₁₀ alkyl; n-propyl or C₄ -C₇ alkyl substituted with one or more halogen, OR⁸, SR⁹ or NR¹⁰ R¹¹ ; C₁ -C₃ alkyl substituted with OR¹⁶, CO₂ (C₁ -C₂ alkyl) or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; C₃ -C₆ cycloalkyl; CH₂ (C₃ -C₆ cycloalkyl); phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; C₂ -C₆ alkenyl optionally substituted with one or more halogen or CO₂ (C₁ -C₂ alkyl); OR¹² ; SR¹³ ; or NR¹⁴ R¹⁵ ;

R⁴ is H, C₁ -C₂ alkyl, ##STR3##

R⁶, R⁷, R⁸, R⁹, R¹⁰ and R¹¹ are independently H or C₁ -C₂ alkyl;

R¹² and R¹³ are independently C₂ -C₁₀ alkyl optionally substituted with one or more halogen, OR⁸, SR⁹ or NR¹⁰ R¹¹ ; phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; or benzyl;

R¹⁴ and R¹⁵ are independently H or C₁ -C₂ alkyl, or may be taken together as --(CH₂)₄ --, --(CH₂)₅ -- or --(CH₂ CH₂ OCH₂ CH₂)--;

R¹⁶ is H, C₁ -C₈ alkyl; benzyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen;

R¹⁷ is H, C₁ -C₂ alkyl or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen;

R¹⁸ is H, C₁ -C₂ alkyl, C₃ -C₆ cycloalkyl, CH₂ (C₃ -C₆ cycloalkyl), O(C₁ -C₄ alkyl), O-allyl or may be taken together with R¹⁷ as --(CH₂)₄ --, --(CH₂)₅ -- or --(CH₂ CH₂ OCH₂ CH₂)--;

R¹⁹ is H or C₁ -C₂ alkyl;

R²⁰ is H or C(O)CH₃ ;

R²¹ and R²² are independently H, CN, CO₂ R⁴, C(X)NR¹⁷ R¹⁸ or halogen;

X is O or S;

or their N-oxides or agriculturally suitable salts thereof provided that when R¹ is Cl, Br or I, and R² is CN, CO₂ R⁴ or C(O)NR¹⁷ R¹⁸, then R³ is other than optionally substituted 5-phenyl and at least one of the following: surfactant, solid, or liquid diluent.

This invention also is directed to a method of using the agriculturally suitable compositions for controlling the growth of undesired vegetation in a crop by applying to the locus of the crop an effective amount of the compounds or composition of the invention without the proviso that removes certain structures from the compositions of the invention.

This invention also is directed to herbicidal mixtures of the compounds of the invention with one or two other known herbicides for controlling the growth of undesired vegetation in a rice crop. The preferred mixtures of the invention comprise a compound of Formula I when R¹ is Br or Cl, R² is C(O)NH₂ and R³ is CH₂ CH₂ CH(CH₃)₂, one or more herbicidal compound selected from the group consisting of bensulfuron methyl; mefenacet; metsulfuron methyl; pyrazosulfuron ethyl; butachlor; N-[2-(2-methoxyethoxyphenylsulfonyl]-N¹ -4,6-dimethoxy-1,3,5-triazin-2-yl urea; N-[[(4,6-dimethoxypyrimidin-2-yl)amino]carbonyl]-1-methyl-4-(2-methyl-2H-tetrazol-5-yl)-1H-pyrazole-5-sulfonamide; S,S-dimethyl 2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridinecarbothiate; and 3-chloro-N [[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]imidazo-[1,2-a]pyridine-3-sulfonamide.

In the above definitions, the term "alkyl" includes straight chain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or the different butyl isomers, etc. Cycloalkyl includes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term "halogen" means fluorine, chlorine, bromine or iodine.

The compositions and methods of use that are preferred for reasons including ease of synthesis and/or greater herbicidal efficacy are:

1. The compositions and the methods for controlling the growth of undesired vegetation by applying to the locus of the crop compositions comprising compounds of Formula I wherein

R¹ is Cl, Br, I or OCH₃ ;

R² is CN, CO₂ R⁴, CHO, C(X)NH₂, C(X)NH(C₁ -C₂ alkyl), C(X)N(C₁ -C₂ alkyl)₂, C(S)OR⁶ or C.tbd.CH;

R³ is n-propyl, C₄ -C₆ alkyl, C₃ -C₆ cycloalkyl or phenyl;

R⁴ is H or C₁ -C₂ alkyl; and

R⁶ is C₁ -C₂ alkyl.

2. The compositions and methods of comprising compounds of Formula I wherein

R¹ is Cl, Br or I;

R² is CN, CO₂ H, CO₂ CH₃, CO₂ CH₂ CH₃, CHO, C(O)NH₂, C(O)NHCH₃, C(O)N(CH₃)₂, CH₂ OH or CH═NOR⁷ ;

R³ is n-propyl; C₄ -C₇ alkyl; C₂ alkyl substituted with phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; CH₂ (C₃ -C₆ cycloalkyl); or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen.

3. The compositions and methods of Preferred 2 wherein

R¹ is Cl or Br;

R² is CN, CO₂ H or C(O)NH₂ ;

R³ is C₄ -C₇ alkyl or CH₂ (C₃ -C₆ cycloalkyl).

4. The compositions and methods of Preferred 3 wherein

R³ is substituted at the 6-pyridine position.

5. The compositions and methods of Preferred 4 wherein R² is C(O)NH₂.

Specifically preferred methods of use involve the compounds which are 2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide and 2-chloro-6-(3-methylbutyl)-3-pyridinecarboxamide.

DETAILED DESCRIPTION OF THE INVENTION

Compounds of Formula I wherein R³ is alkyl and where R² is cyano have been synthesized before. The synthesis of 2-chloro-3-cyano-6-isobutylpyridine is described in detail in J. Am. Chem. Soc. (1947), Vol. 69, 2670. It is also shown schematically below (Scheme I). ##STR4##

The synthesis of any variations in R³ would be expected to follow along the same lines. Other substituents for R² may be synthesized using a variety of transformations on 2.

Alternatively, the compounds of type 2 where R³ is phenyl or substituted phenyl (as described) can be synthesized by first treatment of methyl ketone of R³ with dimethylformamide dimethylacetal at a temperature from 25°-100° C. for 2-48 hours to form an intermediate as described in Tetrahedron (1979), 1675 which upon treatment with cyanoacetamide under acidic conditions such as acetic acid or hydrochloric acid in a solvent such as toluene, benzene or tetrahydrofuran at a temperature 25° to 110° for 2-48 hours to provide compound of type 2 (Scheme Ia). ##STR5##

The compound 2 can either be treated with triphenylphosphine and carbon tetrachloride at a temperature 25°-100° for 2-48 hours or treatment with a mixture of phosphorus oxychloride and phosphorus pentachloride at a temperature 25° to 100° for 2-24 hours to provide compounds of type 1.

The compound 2 can be treated with chlorodifluoromethane or chlorotrifluoromethane to provide compound 1 where R¹ is OCF₂ H or OCF₃, respectively, by following the literature references J. Heterocyclic Chem. 1990, 27, 807; Synthesis 1990, 604 and 681. The cyano group may be hydrolyzed to a carboxylic acid according to the aforementioned paper. Subsequent treatment of the acid with a mixture of phosphorus oxychloride and phosphorus pentachloride converts the acid to the acid chloride and exchanges the hydroxy group for a chlorine atom to provide 3 (Scheme II; J. Med. Chem. (1979), Vol. 22, 525). Alternatively, treatment of the acid with phosphorus tribromide would be expected to provide the corresponding 2-bromo-pyridine compound. Acid chloride 3 may be treated with an alcohol R⁶ --OH to provide the corresponding ester under conditions well known to those versed in the art. In analogous fashion, 3 may be treated with ammonia or a primary or secondary amine, R¹⁷ R¹⁸ NH, ##STR6## to provide the corresponding amide. The thioesters and thioamides of this family may be synthesized via treatment of the aforementioned esters and amides with Lawesson's reagent (Tetrahedron (1979), 2433 and references cited therein).

Alternatively the cyano group of 1 can be converted to an amide according to J. Med. Chem. 1985, 28, 1790 using 30% aqueous hydrogen peroxide, methanol and sodium hydroxide system or Synthesis 1989, 950, using 30% hydrogen peroxide, potassium carbonate and dimethylsulfoxide. The cyano group of 1 can be converted to carboxylic acid using about 5-20% aqueous base such as sodium hydroxide or potassium hydroxide, preferably 5% aqueous sodium hydroxide at about 25° to 100° C. for 1 to 24 hours. The carboxylic acid of 1 then can be converted to acid halide 3 which in turn can be converted to substituted amides as shown in Scheme II.

The compound 1 can be treated with sodium methoxide in methanol at about 0° to 80° C. for 1 to 24 hours to provide compounds of Formula I where R¹ ═OCH₃, R² ═CN and R³ is as described.

The 2-Cl of compound 1 can be exchanged with iodide by using sodium iodide or potassium iodide in a solvent such-as acetone or methylethylketone at about 25° to 120° C. for 1 to 48 hours.

More variety and flexibility of synthesis may be provided by reduction of the cyano group to aldehyde 4 with diisobutylaluminum hydride (DIBAL-H) according to standard procedures known to one skilled in the art as shown in Scheme III. The secondary alcohol can be prepared by treatment of the aldehyde 4 with (C₁ -C₂ alkyl)-MgBr.

The aldehyde 4 can be converted to oximes with treatment of NH₂ OR⁷ to provide 4A and to olefins 4B upon treatment with active methylene compounds of type CH₂ R²¹ R²² (wherein R²¹ or R²² is a nitrile, ester or amide) and a base by one skilled in the art. The acetylene may be synthesized from the aldehyde via the Corey-Fuchs homologation as shown in Scheme III (CBr₄ /PPh₃ to form dibromoolefin, followed by n-BuLi, rearrangement and quench with acid; see Tetrahedron Lett. (1972), 3769). ##STR7##

The 2-chloro-3-cyano-6-methyl pyridine can be converted to primary bromide 4C by treatment with one equivalent of N-bromosuccinimide in a solvent such a dichloromethane or carbon tetrachloride at a temperature 25° to 100° C. for 1 to 24 hours. The resulting bromide can be utilized to form compounds of type 4D as shown in Scheme IIIa. Thus 4C can be treated with a base such as triethylamine, pyridine or sodium hydride and a C₁ -C₈ alcohol in a solvent such as tetrahydrofuran, dimethylformamide or dioxane at about 0° to 100° C. ##STR8##

The compounds of type 4G can be synthesized by reacting compound 4F under basic conditions with alcohols, phenols, mercaptans, thiophenols and substituted amines as shown in Scheme IIIb. The synthesis of 4F is known (Agnew Chem. Int. Ed. Engl. 1980 388). ##STR9##

The pyridines with an alkyl substituent on the 5-position may be synthesized by following literature reference J. Org. Chem. (1978) 43 (12) 2529 and U.S. Pat. No. 4,987,232 and as shown in Scheme IV. The 3-ethoxy-2-alkyl propenals may be synthesized according to a literature procedure (Tetrahedron Lett (1984), 5243). Treatment of this aldehyde with cyanoacetamide would provide, after acid catalyzed cyclization, the intermediate 5. ##STR10## Intermediate 5 may then be elaborated to the required pyridines by the same transformations as already described in Schemes II and III.

The pyridines with an alkyl substituent on the 4-position may be synthesized as shown in Scheme V. ##STR11##

Ethyl cyanoacetate and orthoesters will condense to form the 3-alkoxy, -3-alkylidene derivatives with distillation of alcohol. (Chem. Abs. 52:11909i, U.S. Pat. No. 2,824,121). Condensation with an acetaldehyde equivalent such as the corresponding enamel or silyl ether followed by ammoniolysis should provide 6. Further elaboration of 6 according to procedures described in Schemes II and III would provide quantities of the required pyridines.

The preparation of the compounds of this invention is further illustrated by the following specific examples. Unless otherwise indicated, temperatures are in degrees centigrade.

EXAMPLE 1 1,2-Dihydro-2-oxo-6-(3-methylbutyl)-3-pyridine carbonitrile

To a suspension of 23.25 g of sodium methoxide in 500 mL of diethylether under a nitrogen atmosphere and at 0° C., a solution of 29.6 g of ethylformate and 45.6 g 4-methyl-2-pentanone in 100 mL of diethylether was added dropwise while maintaining the reaction temperature at 0° C. After stirring at 25° C. for 2 hours a heavy precipitate formed. The diethylether was removed and to the residual solid was added a solution of 33.4 g cyanoacetamide in 150 mL water and piperidine acetate (prepared by adding piperidine to 4 mL of glacial acetic acid in 20 mL water until the solution is just basic to litmus). The mixture was heated under reflux for 2 hours. At the end of this time 100 mL of water was added and the solution was acidified (to litmus) with acetic acid, causing separation of product as yellow precipitate. The mixture was cooled in an ice bath for 2 hours and product was collected on suction filter, washed with 3×100 mL water, suction-dried and finally dried in vacuo at 25° C. overnight to afford 54 g of the title compound as a yellow solid; m.p. 110°-112° C.

NMR (CDCl₃) ppm δ 7.82 (d, 1H); 6.23 (d, 1H); 2.73 (d, 2H), 1.67 (m, 3H); 0.996 (d, 6H).

IR (Nujol): 2200 cm⁻¹ (C.tbd.N), 1650 cm⁻¹ (C═O).

EXAMPLE 2 Compound 8

The suspension of 15.2 g of the compound of Example 1 in 22 mL of phosphorus oxychloride was heated at 90° C., and 19 g of phosphorus pentachloride was added in small portions over a 30-minute period. The mixture was heated at 90° C. for additional 1.5 hours and excess phosphorus oxychloride was removed in vacuo. The residue was dissolved in (1:1) 200 mL methylene chloride and 200 ml water. The methylene chloride layer was collected, washed with water, dried over magnesium sulfate, filtered and the filtrate evaporated to leave yellow oil. Silica gel flash column chromatography (8:2 hexane-ethylacetate) afforded after evaporation of the eluant 11.55 g of the subject compound as a brown oil.

NMR (CDCl₃) ppm δ 7.9 (d, 1H); 7.23 (d, 1H); 2.87 (m, 2H); 1.64 (m, 3H); 0.965 (d, 6H).

IR (Neat): 2210 cm⁻¹ (C.tbd.N).

EXAMPLE 3 Compound 13

To 1.95 g of the compound of Example 2 in 15 mL of methanol, a solution of 0.5 g sodium hydroxide in 2 mL of water was added followed by 2.2 mL of 30% aqueous hydrogen peroxide at 25° C. The reaction mixture was stirred for 24 hours and 50 mL of water was added and the mixture was extracted with 2×25 mL of methylene chloride. The methylene chloride extracts were washed with 25 mL each of aqueous saturated sodium bisulfite and water. The organic layer was dried over magnesium sulfate, filtered and the filtrate was evaporated to yield 1.2 g of title compound as a white solid, m.p. 119°-120° C.

NMR (CDCl₃) ppm δ 8.2 (d, 1H); 7.2 (d, 1H); 6.85 (s, 1H); 6.0 (s, 1H); 2.77 (m, 2H); 1.6 (m, 3H); 0.965 (d, 6H).

IR (Nujol): 3320, 1650 cm⁻¹ (C═O).

EXAMPLE 4 Compound 34

To a solution of 7.36 g 'sodium hydroxide in 147 mL water, 8.68 g of compound of Example 2 was added and heated to reflux for 4 hours. The mixture was cooled to 0° C. (ice bath) and acidified to pH 2 (litmus) with concentrated hydrochloric acid. The mixture was then extracted with 3×100 mL methylene chloride. The organic extracts were washed with 50 ml each of water and saturated sodium chloride solution. The organic layer was dried over magnesium sulfate, filtered and filtrate was evaporated to afford 8.0 g of the title compound as a yellow oil.

NMR (CDCl₃) ppm δ 8.28 (d, 1H); 7.23 (d, 1H); 2.8 (m, 2H); 1.6 (m, 2H); 1.2 (m, 1H); 0.97 (d, 6H).

IR (Neat): 1700 cm⁻¹, (C═O).

EXAMPLE 5 Compound 39

By the procedure of Example 2, 15.2 g of the product of Example 1 was reacted with 40 g phosphorus oxybromide and 10 g of phosphorus pentabromide. The isolated crude product was purified by silica gel flash column chromatography (hexanes:ethylacetate 8:2) to afford after evaporation of the eluant 13.0 g of title compound as a dark brown oil.

NMR (CDCl₃) ppm δ 7.8 (d, 1H); 7.2 (d, 1H); 2.8 (t, 2H); 1.6 (m, 3H), 0.9 (d, 6H).

IR (Neat): 2220 cm⁻¹ (C.tbd.N).

EXAMPLE 6 Compound 41

By the procedure of Example 3, 1.6 g of the product of Example 5 was reacted with 0.3 g sodium hydroxide in 1.2 mL of water and 1.4 mL of 30% aqueous hydrogen peroxide. The isolated crude product was purified by silica gel flash column chromatography (hexane:ethylacetate 1:1) to provide after evaporation of the eluant 0.64 g of title compound as a white solid, m.p. 110°-112° C.

NMR (CDCl₃) ppm δ 8.0 (d, 1H); 7.2 (d, 1H); 6.5 (b, s, 1H); 6.0 (b, s, 1H); 2.8 (m, 2H); 1.6 (m, 3H); 0.96 (d, 6H).

IR (Neat): 3340 cm⁻¹ (NH₂); 1650 cm⁻¹ (C═O).

Using the procedures of Schemes I-V and Examples 1-6, one skilled in the art can prepare the compounds in Tables 1-3.

       TABLE 1       ##STR12##         R.sup.1 = Cl, R.sup.2 = C (O) NH.sub.2 R.sup.3 R.sup.3 R.sup.3      cyclopropyl CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6       H.sub.4) (CH.sub.2).sub.2 CH.sub.3 cyclobutyl CH.sub.2 S(2ClC.sub.6      H.sub.4) (CH.sub.2).sub.3 CH.sub.3 cyclopentyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) (CH.sub.2).sub.4 CH.sub.3 cyclohexyl CH.sub.2       S(2,4ClC.sub.6 H.sub.3) (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 S(3SCH.sub.3 C.sub.6 H.sub.4) (CH.sub.2).sub.6      CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,6ClC.sub.6      H.sub.3) (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 S(C.sub.6 H.sub.5) (CH.sub.2).sub.8 CH.sub.3 CH.sub.2 OCH.sub.2      (C.sub. 6 H.sub.5) CH.sub.2 S(3CF.sub.3 C.sub.6       H.sub.4) (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 OCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2      S(4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(2,6ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       OCH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 S(2,4ClC.sub.6 H.sub.3)      CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      OCH.sub.2 (2,4FC.sub.6 H.sub.3) CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2      CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub. 5)      CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.3 CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2      CH.sub.3 CH.sub.2 O(2ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2       O(3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 NH(C.sub.6 H.sub.5) CH.sub.2      CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6      H.sub.4) CH.sub.2 NH(2ClC.sub.6 H.sub.4) CH.sub.2 CF.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(4ClC.sub.6 H.sub.4) CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2      CH.sub.3 CH.sub. 2 O(2,4ClC.sub.6 H.sub.3) OCH.sub.2 CH.sub.2 CH.sub.3      CH.sub.2 -cyclopropyl CH.sub.2 SCH.sub.2 CH.sub.3 OCH.sub.2       (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 -cyclobutyl CH.sub.2 SCH.sub.2      CH.sub.2 CH.sub.3 OCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       -cyclopentyl CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 -cyclohexyl CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) OCH.sub.2 C(C.sub.6 H.sub.5) R.sup.3 R.sup.3 R.sup.3      OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (C.sub.6 H.sub.5)      2ClC.sub.6 H.sub.4 OCH.sub.2 (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6 H.sub.4 O(C.sub.6      H.sub.5) NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6      H.sub.4 O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (2,4ClC.sub.6 H.sub.3)      2,4ClC.sub.6 H.sub.3 O(2ClC.sub.6 H.sub.4) NHCH.sub.2 (2,6ClC.sub.6      H.sub.3) 2,6ClC.sub.6 H.sub.3 O(4SCH.sub.3 C.sub.6 H.sub.4) NH(C.sub.6      H.sub.5) 2SCH.sub.3 C.sub.6 H.sub.4 O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C      .sub.6 H.sub.4) CH.sub.2 (C.sub.6 H.sub.5) SCH.sub.2 CH.sub.2 CH.sub.3      NH(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2      (CH.sub.2).sub.2 CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2      (2ClC.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6      H.sub.3) CH.sub.2 (4ClC.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.5      CH.sub.3 NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 (2,4ClC.sub.6 H.sub.3)      SCH.sub.2 (C.sub.6 H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) SCH.sub. 2 (3SCH.sub.3 C.sub.6      H.sub.4) N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2OCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6 H.sub.4) SCH.sub.2      (2ClC.sub.6 H.sub.4) N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3)      SCH.sub.2 (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6       H.sub.3) S(CH.sub.3).sub.3 CH.sub.2 CO.sub.2 CH.sub.3 SCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 R.sup.1      = Br, R.sup.2 = C(O)NH.sub.2 S(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.3 R.sup.3 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub. 3 S(2ClC.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 (CH.sub.2).sub.3       CH.sub.3 S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2      CH.sub.3 (CH.sub.2).sub.4 CH.sub.3 S(2,4ClC.sub.6 H.sub.3) CH.sub.2      CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.5       CH.sub.3 S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.6      CH.sub.3 2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2      (CH.sub.2).sub.7 CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2       CHCHCH.sub.3 (CH.sub.2).sub.8 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl (CH.sub.2).sub.9 CH.sub.3 NHCH.sub.2      (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl CH.sub.2      CH(CH.sub.3).sub.2 NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub. 2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 R.sup.3 R.sup.3 CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4) OCH.sub.2       (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4) OCH.sub.2 C(C.sub.6      H.sub.5) CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6 H.sub.3)      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) CH.sub.2 CF.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2      CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) O(2,4ClC.sub.6 H.sub.3) CH.sub.2      cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 -cyclobutyl CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2      (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 S(3SCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       -cyclohexyl CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5      CH.sub.3 cyclopropyl CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) cyclobutyl CH.sub. 2 S(3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2      (3SCH.sub.3 C.sub.6 H.sub.4) cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4)      SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) cyclohexyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (2,4-C.sub.6      H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3      CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH.sub.2      CH.sub.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6      H.sub.5) CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 S(3CF.sub.3  C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) S(2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2 (4ClC.sub.6 H.sub.4)      CH.sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) S(4OCH.sub.3 C.sub.6 H.sub.4)      CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5)      S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3      CH.sub.2 NH(2ClC.sub.6 H.sub.4) S(2,6FC.sub.6 H.sub.3) CH.sub.2       O(C.sub.6 H.sub.5) CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C      .sub.6 H.sub.4) CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 CH.sub.2      CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(4CF.sub.3 C.sub.6      H.sub.4) OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub. 2 (CH.sub.2).sub.3      CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 R.sup.3 R.sup.3 R.sup.3      NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5  CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      (C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2       CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6      H.sub.4 CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 NHCH.sub.2      (4CH.sub.3 C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.3 NHCH.sub.2 (2,4ClC.sub.6       H.sub.3) 2,4ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 NHCH.sub.2 (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3      CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 NH(C.sub.6 H.sub.5)      2SCH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3      NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2      CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 NH(2ClC.sub.6 H.sub.4) CH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2      NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3) CH.sub.2      (4ClC.sub.6 H.sub.4) CH.sub.2 -cyclopropyl NH(2,6ClC.sub.6 H.sub.3)      CH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2       -cyclobutyl N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3 C      .sub.6 H.sub.4) CH.sub.2 -cyclopentyl N(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 (3OCH.sub.3  C.sub.6 H.sub.4) CH.sub.2 -cyclohexyl      N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6       H.sub.4) cyclopropyl N(CH.sub.2).sub.5  CH.sub.2 (2,6FC.sub.6 H.sub.3)      cyclobutyl N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6 H.sub.3) cyclopentyl      N(CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6      H.sub.3) cyclohexyl CH.sub.2 CO.sub.2 CH.sub.3  CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 R.sup.1 = I,      R.sup.2 = C(O)NH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      CH.sub.2 CO.sub.2 CH.sub.3 R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2      OCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3      (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2 ).sub.4 CH.sub.3      CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2       N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.5 CH.sub.3 CH.sub.2      OCH.sub.2 (3SCH.sub.3 C.sub.6       H.sub.4) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.6 CH.sub.3 CH.sub.2      OCH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2        (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3)      CH.sub.2 CHCHCH.sub.3 (CH.sub.2).sub.8 CH.sub.3 CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2 CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl (CH.sub.2).sub.9      CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4)      R.sup.3 R.sup.3 R.sup.3 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2      (CH.sub.2).sub.2 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2      O(2ClC.sub. 6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2      (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4)      OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3      CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4) OCH.sub.2 C(C.sub.6 H.sub.5)      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(4ClC.sub.6 H.sub.4) OCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2        C      O(2,4Cl.sub.6 H.sub.3) OCH.sub.2 (2ClC.sub.6 H.sub.4) NHCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 SCH.sub.2 CH.sub.3 OCH.sub.2      CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 SCH.sub.2      CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5) NHCH.sub.2 4CH.sub.3 C.sub.6      H.sub.4) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C.sub.6 H.sub.4)      NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2 SCH.sub.2 (C.sub.6 H.sub.5)      O(2ClC.sub.6 H.sub.4) NHCH.sub.2 (2,6ClC.sub.6 H.sub.3) CH.sub.2      SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) O(4SCH.sub.3 C.sub.6 H.sub.4)      NH(C.sub.6 H.sub.5) CH.sub.2 S(2ClC.sub.6 H.sub.4) O(2,4ClC.sub.6      H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(4CH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6 H.sub.4) CH.sub.2      S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 NH(3CH.sub.3 C      .sub.6 H.sub.4) CH.sub.2 S(3SCH.sub.3 C.sub.6 H.sub.4) SCH.sub.2      (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3) CH.sub.2       S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5       CH.sub.3 NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2      (C.sub.6 H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      S(3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4)      N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4)      SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.2).sub.4 CH.sub.2      S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6       H.sub.4) N(CH.sub.2).sub.5 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2      (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 S(2,4ClC.sub.6 H.sub.3)      SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2).sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3 CH.sub.2      CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 SCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 S(3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2       NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) S(2ClC.sub.6 H.sub.4) CH.sub.2      CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4)      S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3      CH.sub.2 NH(C.sub.6 H.sub.5) S(2,4ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2      N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6       H.sub.4) S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CHCH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 CHCHCH.sub.3 R.sup.3 R.sup.3 R.sup.3 CHCHCH.sub.2      CH.sub.2 Cl (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(3CF.sub.3 C.sub.6 H.sub.4)  C.sub.6 H.sub.5 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4) 3CF.sub.3      C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(2ClC.sub.6 H.sub.4) 2ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2       CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4) 3OCH.sub.3      C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      O(4ClC.sub.6 H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6       H.sub.3) 2,4ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 2,6ClC.sub.6 H.sub.3 CH.sub.2      CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub. 2 CH.sub.2      CH.sub.3 2SCH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 (C.sub.6 H.sub.5)      CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CF.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2      CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2 (4ClC.sub.6 H.sub.4)      CH.sub.2 -cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2      (2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclobutyl CH.sub.2 S(2,4ClC.sub.6      H.sub.3) CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 -cyclopentyl      CH.sub.2 S(3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3OCH.sub.3 C.sub.6      H.sub.4) CH.sub.2 -cyclohexyl CH.sub.2 S(2,6ClC.sub.6 H.sub.3) CH.sub.2      (3ClC.sub.6 H.sub.4) cyclopropyl CH.sub.2 S(C.sub.6 H.sub.5) CH.sub.2      (2,6FC.sub.6 H.sub.3) cyclobutyl CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (2,6ClC.sub.6 H.sub.3) cyclopentyl CH.sub.2 S(2ClC.sub.6      H.sub.4) CH.sub.2 (3,4FC.sub.6 H.sub.3) cyclohexyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4)  CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 S(2,6ClC.sub.6      H.sub.3) R.sup.1 = OCH.sub.3, R.sup.2 = C(O)NH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6 H.sub.3) R.sup.3 CH.sub.2      OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5)      CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 C(C.sub.6      H.sub.5) (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.5      CH.sub.3 CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2      NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) (CH.sub.2).sub.6 CH.sub.3      CH.sub.2 OCH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (2ClC.sub.6      H.sub.4) (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6      H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5) (CH.sub.2).sub.8 CH.sub.3 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6 H.sub.4)      R.sup.3 R.sup.3 R.sup.3 CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4)      2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2  OCH.sub.2      CH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CHCHCH.sub.3      OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3      CHCHCH.sub. 2 CH.sub.2 Cl OCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2      (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl OCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 C.sub.6      H.sub.5 OCH.sub.2 C(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2 (3CF.sub.3 C.sub.6       H.sub.4) NHCH.sub.2 (C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4 OCH.sub.2      (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) 3CH.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6      H.sub.4) 3OCH.sub.3 C.sub.6 H.sub.4 O(C.sub.6 H.sub.5) NHCH.sub.2      (4CH.sub.3 C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 O(3CF.sub.3      C.sub.6 H.sub.4) NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6 H.sub.3      O(2ClC.sub.6 H.sub.4) NHCH.sub.2 (2,6ClC.sub. 6 H.sub.3) 2,6ClC.sub.6      H.sub.3 O(4SCH.sub.3 C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) 2SCH.sub.3      C.sub.6 H.sub.4 O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (C.sub.6 H.sub.5) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6      H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4)      SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3) CH.sub.2      (4ClC.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NH(2,6ClC.sub.6      H.sub.3) CH.sub.2 (2,4ClC.sub.6 H.sub.3) SCH.sub.2 (C.sub.6 H.sub.5)      N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3 C.sub.6 H.sub.4) SCH.sub.2      (2OCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.2)4 CH.sub.2 (3ClC.sub.6 H.sub.4)      SCH.sub.2 (2ClC.sub.6 H.sub.4) N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6      H.sub.3) SCH.sub.2 (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2      (2,6ClC.sub.6 H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6 H.sub.3)      S(CH.sub.3).sub.3 CH.sub.2 CO.sub.2 CH.sub.3 SCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 R.sup.1      = OCF.sub.2 H, R.sup.2 = C(O)NH.sub.2 S(C.sub.6 H.sub.5) CH.sub.2      CH.sub.2 CO.sub.2 CH.sub.3 R.sup.3 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 S(2ClC.sub.6      H.sub.4) CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3      S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3      (CH.sub.2).sub.4 CH.sub.3 S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2      N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.5 CH.sub.3 S(2,6FC.sub.6      H.sub.3) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.6 CH.sub.3 R.sup.3 R.sup.3      R.sup.3 (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6      H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5) (CH.sub.2).sub.8 CH.sub.3 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6 H.sub.4)      (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4)      OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub. 2       CH(CH.sub.3).sub.2 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2       (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4) OCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4) OCH.sub.2 C(C.sub.6      H.sub.5) CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6 H.sub.3)      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) CH.sub.2 CF.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2      CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) O(2,4ClC.sub.6 H.sub.3) CH.sub.2      -cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 -cyclobutyl CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2      (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 S(3SCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       -cyclohexyl CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5      CH.sub.3 cyclopropyl CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) cyclobutyl CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4 ) SCH.sub.2      (3SCH.sub.3 C.sub.6 H.sub.4) cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4)      SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) cyclohexyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (2,4-C.sub.6      H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3      CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH.sub.2      CH.sub.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6      H.sub.5) CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) S(2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2 (4ClC.sub.6 H.sub.4)      CH.sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) S(4OCH.sub.3 C.sub.6 H.sub.4)      R.sup.3 R.sup.3 R.sup.3 S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2      N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.5 CH.sub.3 S(2,6FC.sub.6      H.sub.3) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.6 CH.sub.3 2(3CH.sub.3      C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2  (CH.sub.2).sub.7 CH.sub.3      NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CHCHCH.sub.3 (CH.sub.2).sub.8      CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl      (CH.sub.2).sub.9 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2      CH.sub.2 CHClCH.sub.2 Cl CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       (CH.sub.2).sub. 5 CH.sub.3 C.sub.6 H.sub.5 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      (C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2       CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6      H.sub.4 CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 NHCH.sub.2      (4CH.sub.3 C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.3 NHCH.sub.2 (2,4ClC.sub.6       H.sub.3) 2,4ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 NHCH.sub.2 (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3      CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 NH(C.sub.6 H.sub. 5)      2SCH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3      NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2      CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 NH(2ClC.sub.6 H.sub.4) CH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2      NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3) CH.sub.2      (4ClC.sub.6 H.sub.4) CH.sub.2 -cyclopropyl NH(2,6ClC.sub.6 H.sub.3)      CH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2       -cyclobutyl N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3 C      .sub.6 H.sub.4) CH.sub.2 -cyclopentyl N(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 (3OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 -cyclohexyl      N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6       H.sub.4) cyclopropyl N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3)      cyclobutyl N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6 H.sub.3) cyclopentyl      N(CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6      H.sub.3) cyclohexyl CH.sub.2 CO.sub.2 CH.sub.3  CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 R.sup.1 = Cl,      R.sup.2 = CN CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.3 R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 OCH.sub.2      (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2       OCH.sub.2 (2ClC.sub.6 H.sub.4) R.sup.3 R.sup.3 R.sup.3  CH.sub.2      OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) S(2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2 (4ClC.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) S(4OCH.sub.3 C.sub.6      H.sub.4) CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3) CH.sub.2 NH(C.sub.6      H.sub.5) S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 NH(2ClC.sub.6 H.sub.4) S(2,6FC.sub.6 H.sub.3) CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3      C.sub.6 H.sub.4) CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2      CH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(4CF.sub.3      C.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 NHCH.sub.2       (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2      (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2      O(3SCH.sub.3 C.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3      NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6      H.sub.4) OCH.sub.2 C(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      NHCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 O(2,4ClC.sub.6 H.sub.3) OCH.sub.2      (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 SCH.sub.2 CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5)      NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2      SCH.sub.2 (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) NHCH.sub. 2       (2,6ClC.sub.6 H.sub.3) CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) CH.sub.2 S(2ClC.sub.6      H.sub.4) O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6      H.sub.4) CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3SCH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3)      CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3      NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3CF.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.3      )CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) SCH.sub.2      (2OCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.2).sub.4 CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) N(CH.sub.2).sub.5      CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (2,4-C.sub.6 H.sub.3)      N(CH.sub.2).sub.6 CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (4CF.sub.3      C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2      NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3 CH.sub.2 CO.sub.2 CH.sub.3      CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 SCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2      C(C.sub.6 H.sub.5) S(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CO.sub.2      CH.sub.3 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 S(3CF.sub.3 C.sub.6      H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 R.sup.3 R.sup.3 R.sup.3      CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2      CH.sub.3 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.5      CH.sub.3 CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6       H.sub.4) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.6 CH.sub.3 CH.sub.2      OCH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2        (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3)      CH.sub.2 CHCHCH.sub.3 (CH.sub.2).sub.8 CH.sub.3 CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2 CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl (CH.sub.2).sub.9      CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4)      C.sub.6 H.sub.5  CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       O(4CF.sub.3 C.sub.6 H.sub.4) 3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(2ClC.sub.6 H.sub.4)      2ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4) 3CH.sub.3 C.sub.6      H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      O(2CH.sub.3 C.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6 H.sub.4 CH.sub.2      CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2 O(4ClC.sub.6 H.sub.4)      2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3      CH.sub.2 O(2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2      CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 2,6ClC.sub.6      H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.      2 CH.sub.2 CH.sub.3 2SCH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2      CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2      (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3      CH.sub.2 SCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4)      CH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 -cyclopropyl CH.sub.2 S(4CH.sub.3 C      .sub.6 H.sub.4) CH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclobutyl      CH.sub.2 S(2,4ClC.sub.6 H.sub.3) CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4)      CH.sub.2 -cyclopentyl CH.sub.2 S(3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2      (3OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 -cyclohexyl CH.sub.2       S(2,6ClC.sub.6 H.sub.3) CH.sub.2 (3ClC.sub.6 H.sub.4) cyclopropyl      CH.sub.2 S(C.sub.6 H.sub.5) CH.sub.2 (2,6FC.sub.6 H.sub.3) cyclobutyl      CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2,6ClC.sub.6 H.sub.3)      cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2 (3,4FC.sub.6      H.sub.3) cyclohexyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4)  CH.sub.2      OCH.sub.2 CH.sub.3 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) R.sup.1 = Br,      R.sup.2 = CN CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2       S(2,4ClC.sub.6 H.sub.3) R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2       OCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3      R.sup.3 R.sup.3 R.sup.3 CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6      H.sub.5) CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      S(2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2      NHCH.sub.2 (2ClC.sub.6 H.sub.4) S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 NH(C.sub.6 H.sub.5) S(2,4ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      NH(2ClC.sub.6 H.sub.4) S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2      CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 CHCHCH.sub.3 OCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl      OCH.sub. 2 (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4      CH.sub.3 CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl OCH.sub.2 (CH.sub.2).sub.5      CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5 OCH.sub.2      C(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (C.sub.6      H.sub.5) 2ClC.sub.6 H.sub.4 OCH.sub.2 (2ClC.sub.6 H.sub.4) NHCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6      H.sub.4 O(C.sub.6 H.sub.5) NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4)      2CF.sub.3 C.sub.6 H.sub.4 O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2      (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6 H.sub.3 O(2ClC.sub.6 H.sub.4)      NHCH.sub.2 (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3 O(4SCH.sub.3      C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) 2SCH.sub.3 C.sub.6       H.sub.4 O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      (C.sub.6 H.sub.5) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6 H.sub.4)      CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.2 CH.sub.3      NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) SCH.sub.2      (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6      H.sub.4) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NH(2,6ClC.sub.6 H.sub.3)      CH.sub.2 (2,4ClC.sub.6 H.sub.3) SCH.sub.2 (C.sub.6       H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2OCH.sub. 3 C.sub.6 H.sub.4) N(CH.sub.2)4      CH.sub.2 (3ClC.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6       H.sub.4) N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3) SCH.sub.2      (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6 H.sub.3)      SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6 H.sub.3) S(CH.sub.3).sub.3      CH.sub.2 CO.sub.2 CH.sub.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 R.sup.1 = I, R.sup.2 = CN R.sup.3      R.sup.3 R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 OCH.sub.2      (C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 OCH.sub.2 (3CF.sub.3 C.sub. 6 H.sub.4) CH.sub.2      NHCH.sub.2 C(C.sub.6 H.sub.5) (CH.sub.2).sub.4 CH.sub.3 CH.sub.2      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6       H.sub.4) (CH.sub.2).sub.6 CH.sub.3 CH.sub.2 OCH.sub.2 (4ClC.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) (CH.sub.2).sub.7      CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3) CH.sub.2 NH(C.sub.6      H.sub.5) (CH.sub.2).sub.8 CH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 NH(2ClC.sub.6 H.sub.4) (CH.sub.2).sub.9 CH.sub.3      CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4)      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4)      OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub. 2      CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       O(2ClC.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3      C.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 CH.sub.2       CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6      H.sub.4) OCH.sub.2 C(C.sub.6 H.sub.5) CH.sub.2 CH(CH.sub.2       CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2 O(4ClC.sub.6 H.sub.4) OCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 O(2,4ClC.sub.6 H.sub.3) OCH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.2 SCH.sub.2      CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub. 2 CH.sub.2 CH.sub.3 O(C.sub.6      H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2       SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 (C.sub.6 H.sub.5)      O(2ClC.sub.6 H.sub.4) CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) O(4SCH.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6      H.sub.4) O(2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclopropyl CH.sub.2       S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      -cyclobutyl CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 S(3SCH.sub.3 C.sub.6 H.sub.4)      SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 -cyclohexyl CH.sub.2        C      S(2,6Cl.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 cyclopropyl      CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6 H.sub.5) cyclobutyl      CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6      H.sub.4) cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4) SCH.sub.2       (2OCH.sub.3 C.sub.6 H.sub.4) cyclohexyl CH.sub.2 S(4CH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2 CH.sub.3      CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (2,4-C.sub.6 H.sub.3)      CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6 H.sub.3)      SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) R.sup.3 R.sup.3 R.sup.1 =       OCH.sub.3, R.sup.2 = CN S(CH.sub.3).sub.3 CH.sub.2 CO.sub.2 CH.sub.3      R.sup.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2      CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 S(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 S(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 (CH.sub.2).sub.4       CH.sub.3 S(2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3      (CH.sub.2).sub.5 CH.sub.3 S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.6 CH.sub.3 S(2,4ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.7      CH.sub.3 S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.8      CH.sub.3 2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2      (CH.sub.2).sub.9 CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2       CHCHCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 CH.sub.2 CH ClCH.sub.2 Cl      CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5 CH.sub.2 CH.sub.2       CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 NHCH.sub.2 (C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4 CH.sub.2      CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.3 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 NHCH.sub.2 (4CH.sub.3      C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.2 CH.sub.3 NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6      H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 NHCH.sub.2      (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2      NHCH.sub.2 CH.sub.3 NH(C.sub.6 H.sub.5) 2SCH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2 NH(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3      NH(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      -cyclopropyl NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 -cyclobutyl NH(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6      H.sub.4) CH.sub.2 -cyclopentyl NH(2,6ClC.sub.6 H.sub.3) CH.sub.2      (2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclohexyl N(CH.sub.3)(3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) cyclopropyl      N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3 C.sub.6      H.sub.4) cyclobutyl N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6 H.sub.4)      cyclopentyl N(CH.sub.2 ).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3) cyclohexyl      N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6 H.sub.3) CH.sub.2 OCH.sub.2      CH.sub.3 N(CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2       (3,4FC.sub.6 H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 R.sup.3      R.sup.3 R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3 CH.sub.2 OCH.sub.2 (C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 SCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6 H.sub.5) CH.sub.2      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) S(2ClC.sub.6      H.sub.4) CH.sub.2 OCH.sub.2 (4ClC.sub. 6 H.sub.4) CH.sub.2 NHCH.sub.2      (2ClC.sub.6 H.sub.4) S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      (2,4FC.sub.6 H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5) S(2,4ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2       NH(2ClC.sub.6 H.sub.4) S(2,6FC.sub.6 H.sub.3) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C.sub.6      H.sub.4) CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 CH.sub.2      CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(4CF.sub.3 C.sub.6      H.sub.4) OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.3      CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 O(3SCH.sub.3      C.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NHCH.sub.2       (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4)      OCH.sub.2 C(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      C      O(4Cl.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2      (C.sub.6 H.sub.5) CH.sub.2 O(2,4ClC.sub.6 H.sub.3) OCH.sub.2 (2ClC.sub.6      H.sub.4) NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 SCH.sub.2      CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 SCH.sub.2 CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5) NHCH.sub.2      (4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C      .sub.6 H.sub.4) NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) NHCH.sub.2 (2,6ClC.sub.6      H.sub.3) CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) O(4SCH.sub.3      C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) CH.sub.2 S(2ClC.sub. 6 H.sub.4)      O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2       S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6      H.sub.4) CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3SCH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3)      CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3      NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3CF.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6      H.sub.4) SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.2).sub.4      CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub. 4) SCH.sub.2 (2ClC.sub.6 H.sub.4)      N(CH.sub.2).sub.5 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2       (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 S(2,4ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2).sub.2 R.sup.3 R.sup.1 = OCF.sub.3, R.sup.2 = CN      R.sup.3 CH.sub.2 CO.sub.2 CH.sub.3 R.sup.3 CH.sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3      (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2      CH.sub.2 CO.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 OCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3      (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 (CH.sub.2).sub. 5 CH.sub.3 CH.sub.2      OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2      CH.sub.3 (CH.sub.2).sub.6 CH.sub.3 CH.sub.2 OCH.sub.2 (4ClC.sub.6      H.sub.4) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.7      CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2      (CH.sub.2).sub.8 CH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3      CH.sub.2 CH.sub.2 CHCH.sub.2 (CH.sub.2).sub.9 CH.sub.3 CH.sub.2       O(C.sub.6 H.sub.5) CH.sub.2 CHCHCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4) CHCHCH.sub.2 CH.sub.2 Cl CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl CH.sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(2ClC.sub.6 H.sub.4) C.sub.6 H.sub.5      CH.sub.2 CH.sub.2 CH(CH.sub. 3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      O(3SCH.sub.3 C.sub.6 H.sub.4) 3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2      CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6      H.sub.4) 2ClC.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2      CH.sub.3 CH.sub.2 O(4ClC.sub.6 H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6      H.sub.3) 3OCH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2      CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2      CH.sub.3 2,4ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 2,6ClC.sub.6 H.sub.3 CH.sub.2      CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 (C.sub.6      H.sub.5) 2SCH.sub.3 C.sub. 6 H.sub.4 CH.sub.2 CF.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3      CH.sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 -cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2     C      (2Cl.sub.6 H.sub.4) CH.sub.2 -cyclobutyl CH.sub.2 S(2,4ClC.sub.6      H.sub.3) CH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 -cyclopentyl CH.sub.2      S(3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2      -cyclohexyl CH.sub.2 S(2,6ClC.sub.6 H.sub.3) CH.sub.2 (3SCH.sub.3      C.sub.6 H.sub.4) cyclopropyl CH.sub.2 S(C.sub.6 H.sub.5) CH.sub.2      (3OCH.sub.3 C.sub.6 H.sub.4) cyclobutyl CH.sub.2 S(3CF.sub.3 C.sub.6      H.sub.4) CH.sub.2 (3ClC.sub.6 H.sub.4) cyclopentyl CH.sub.2 S(2ClC.sub.6      H.sub.4) CH.sub.2 (2,6FC.sub.6 H.sub.3) cyclohexyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) CH.sub.2 (2,6ClC.sub.6 H.sub.3) CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) CH.sub.2 (3,4FC.sub.6 H.sub.3)      CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6 H.sub.3)      R.sup.3 R.sup.3 R.sup.3 CH.sub.2 NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3      CH.sub.2 CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3      SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6 H.sub.5)      CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      S(2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2      NHCH.sub.2 (2ClC.sub.6 H.sub.4) S(4OCH.sub.3  C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 NH(C.sub.6 H.sub.5) S(2,4ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      NH(2ClC.sub.6 H.sub.4) S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2      CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 CHCHCH.sub.3 OCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl      OCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3      CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3      NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5 OCH.sub.2 C(C.sub.6      H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4      OCH.sub.2 (3CF.sub. 3 C.sub.6 H.sub.4) NHCH.sub.2 (C.sub.6 H.sub.5)      2ClC.sub.6 H.sub.4 OCH.sub.2 (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6 H.sub.4 O(C.sub.6      H.sub.5) NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6      H.sub.4 O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (2,4ClC.sub.6 H.sub.3)      2,4ClC.sub.6 H.sub.3 O(2ClC.sub.6 H.sub.4) NHCH.sub.2 (2,6ClC.sub.6      H.sub.3) 2,6ClC.sub.6 H.sub.3 O(4SCH.sub.3 C.sub.6 H.sub.4) NH(C.sub.6      H.sub.5) 2SCH.sub.3 C.sub.6 H.sub.4 O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C      .sub.6 H.sub.4) CH.sub.2 (C.sub.6 H.sub.5) SCH.sub.2 CH.sub.2 CH.sub.3      NH(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) SCH.sub. 2      (CH.sub.2).sub.2 CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2      (2ClC.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6      H.sub.3) CH.sub.2 (4ClC.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.5      CH.sub.3 NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 (2,4ClC.sub.6 H.sub.3)      SCH.sub.2 (C.sub.6 H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6      H.sub.4) N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2OCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6 H.sub.4) SCH.sub.2      (2ClC.sub.6 H.sub.4) N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3)      SCH.sub.2 (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4 ) N(CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6 H.sub.3) R.sup.1 =      OCF.sub.2 H, R.sup.2 = CN R.sup.3 R.sup.3 R.sup.3 CH.sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.2      CH.sub.3 CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2      CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 OCH.sub.2       (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5)      (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.5 CH.sub.3      CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) (CH.sub.2).sub.6 CH.sub.3 CH.sub.2 OCH.sub.2      (4ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (2ClC.sub.6       H.sub.4 ) (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6      H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5) (CH.sub.2).sub.8 CH.sub.3 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6 H.sub.4)      (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4)      OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2       (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4) OCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4) OCH.sub.2 C(C.sub.6      H.sub.5) CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6 H.sub.3)      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) CH.sub.2 CF.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub. 2 CH.sub.2 CF.sub.2      CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) O(2,4ClC.sub.6 H.sub.3) CH.sub.2      -cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 -cyclobutyl CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2      (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 S(3SCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       -cyclohexyl CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5      CH.sub.3 cyclopropyl CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) cyclobutyl CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2      (3SCH.sub.3 C.sub.6 H.sub.4) cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4)      SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) cyclohexyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (2,4-C.sub.6      H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) R.sup.3 R.sup.3 R.sup.1      =Cl, R.sup.2 = CO.sub.2 H S(CH.sub.3).sub.3 CH.sub.2 CO.sub.2 CH.sub.3      R.sup.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2      CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 S(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 S(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 (CH.sub.2).sub.4       CH.sub.3 S(2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3      (CH.sub.2).sub.5 CH.sub.3 S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.6 CH.sub.3 S(2,4ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.7      CH.sub.3 S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.8      CH.sub.3 2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2      (CH.sub.2).sub.9 CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2       CHCHCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl      CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5  CH.sub.2 CH.sub.2       CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 NHCH.sub.2 (C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4 CH.sub.2      CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.3 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 NHCH.sub.2 (4CH.sub.3      C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.2 CH.sub.3 NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6      H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 NHCH.sub.2      (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2      NHCH.sub.2 CH.sub.3 NH(C.sub.6 H.sub.5) 2SCH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2 NH(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3      NH(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      -cyclopropyl NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 -cyclobutyl NH(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6      H.sub.4) CH.sub.2 -cyclopentyl NH(2,6ClC.sub.6 H.sub.3) CH.sub.2      (2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclohexyl N(CH.sub.3)(3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) cyclopropyl      N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3 C.sub.6      H.sub.4) cyclobutyl N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6 H.sub.4)      cyclopentyl N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3) cyclohexyl      N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6 H.sub.3) CH.sub.2 OCH.sub.2      CH.sub.3 N(CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2       (3,4FC.sub.6 H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 R.sup.3      R.sup.3 R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3 CH.sub.2 OCH.sub.2 (C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH.sub.2       CH.sub.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6      H.sub.5) CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) S(2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2 (4ClC.sub.6 H.sub.4)      CH.sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) S(4OCH.sub.3 C.sub.6 H.sub.4)      CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5)      S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3      CH.sub.2 NH(2ClC.sub.6 H.sub.4) S(2,6FC.sub.6 H.sub.3) CH.sub.2       O(C.sub.6 H.sub.5) CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C      .sub.6 H.sub.4) CH.sub.2 O(3CF.sub.3 C.sub. 6 H.sub.4) OCH.sub.2      CH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(4CF.sub.3      C.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 NHCH.sub.2       (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2      (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2      O(3SCH.sub.3 C.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3      NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6      H.sub.4) OCH.sub.2 C(C.sub.6 H.sub.4) NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      NHCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 O(2,4ClC.sub.6 H.sub.3) OCH.sub.2      (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 SCH.sub.2 CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5)      NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2      SCH.sub.2 (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) NHCH.sub.2       (2,6ClC.sub.6 H.sub.3) CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) CH.sub.2 S(2ClC.sub.6      H.sub.4) O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6      H.sub.4) CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3SCH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3)      CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2 ).sub.5 CH.sub.3      NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3CF.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6      H.sub.4) SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.2).sub.4      CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4)      N(CH.sub.2).sub.5 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2       (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 S(2,4ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2      OCH.sub.2       CH.sub.2).sub.2

       R.sup.3 R.sup.1 = Br, R.sup.2 = CO.sub.2 H R.sup.3 CH.sub.2 CO.sub.2      CH.sub.3 R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 OCH.sub.2      (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.3 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2      (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 SCH.sub.2       CH.sub.3 (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 OCH.sub.2 (3SCH.sub.3      C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.6      CH.sub.3 CH.sub.2 OCH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2      N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.7 CH.sub.3 CH.sub.2       OCH.sub.2 (2,4FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.8      CH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2      CHCH.sub.2  (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 CHCHCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(3CF.sub.3      C.sub.6 H.sub.4) CHCHCH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CHClCH.sub.2 Cl CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(2ClC.sub.6 H.sub.4) C.sub.6 H.sub.5 CH.sub.2 CH.sub.2      CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6      H.sub.4) 3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4) 2ClC.sub.6      H.sub.4 CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      O(4ClC.sub.6 H.sub.4)  3CH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6 H.sub.3) 3OCH.sub.3      C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.2      SCH.sub.2 CH.sub.3 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2  C      SH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.2 CH.sub.3 2,4ClC.sub.6      H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 2,6ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2      CH.sub.3 CH.sub.2 SCH.sub.2 (C.sub.6 H.sub.5) 2SCH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2      CF.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 -cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub. 6      H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 -cyclobutyl CH.sub.2      S(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2       -cyclopentyl CH.sub.2 S(3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2       (2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclohexyl CH.sub.2 S(2,6ClC.sub.6      H.sub.3) CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) cyclopropyl CH.sub.2      S(C.sub.6 H.sub.5) CH.sub.2 (3OCH.sub.3 C.sub.6 H.sub.4) cyclobutyl      CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3ClC.sub.6 H.sub.4)      cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2 (2,6FC.sub.6      H.sub.3) cyclohexyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2       C      (2,6Cl.sub.6 H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2       S(2,6ClC.sub.6 H.sub.3) CH.sub.2 (3,4FC.sub.6 H.sub.3) CH.sub.2      OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6 H.sub.3) R.sup.3      R.sup.3 R.sup.3  CH.sub.2 NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3 CH.sub.2      CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 SCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 S(3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2       NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) S(2ClC.sub.6 H.sub.4) CH.sub.2      CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4)      S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3      CH.sub.2 NH(C.sub.6 H.sub.5) S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2      N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6       H.sub.4) S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CHCH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 CHCHCH.sub.3 OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3      NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl OCH.sub.2      (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2      CH.sub.2 CHClCH.sub.2 Cl OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NHCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5 OCH.sub.2 C(C.sub.6 H.sub.5)      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (C.sub.6 H.sub.5) 2ClC.sub.6      H.sub.4 OCH.sub.2 (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6      H.sub.4 O(C.sub. 6 H.sub.5) NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4)      2CF.sub.3 C.sub.6 H.sub.4 O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2      (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6 H.sub.3 O(2ClC.sub.6 H.sub.4)      NHCH.sub.2 (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3 O(4SCH.sub.3      C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) 2SCH.sub.3 C.sub.6       H.sub.4 O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      (C.sub.6 H.sub.5) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6 H.sub.4)      CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.2 CH.sub.3      NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) SCH.sub.2      (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6      H.sub.4) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NH(2,6ClC.sub.6 H.sub.3)      CH.sub.2 (2,4ClC.sub.6 H.sub.3)  SCH.sub.2 (C.sub.6       H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2OCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6 H.sub.4) SCH.sub.2      (2ClC.sub.6 H.sub.4) N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3)      SCH.sub.2 (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6 H.sub.3) R.sup.1 = I,      R.sup.2 = CO.sub.2 H R.sup.3 R.sup.3 R.sup.3 CH.sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.2      CH.sub.3 CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2      CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 OCH.sub.2       (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5)      (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.5 CH.sub.3      CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) (CH.sub.2).sub.6 CH.sub.3 CH.sub.2 OCH.sub.2      (4ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (2ClC.sub.6       H.sub.4) (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6      H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5) (CH.sub.2).sub.8 CH.sub.3 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6 H.sub.4)      (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) CH.sub.2 CH(CH.sub.3 ).sub.2 CH.sub.2      O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4)      OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2       (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4) OCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub.4) OCH.sub.2 C(C.sub.6      H.sub.5) CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6 H.sub.3)      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) CH.sub.2 CF.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2      CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) O(2,4ClC.sub.6 H.sub.3) CH.sub.2      -cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 -cyclobutyl CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2      (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 S(3SCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2 ).sub.3 CH.sub.3 CH.sub.2       -cyclohexyl CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5      CH.sub.3 cyclopropyl CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) cyclobutyl CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) SCH.sub.2      (3SCH.sub.3 C.sub.6 H.sub.4) cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4)      SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) cyclohexyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      CH.sub.3 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (2,4-C.sub.6      H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) R.sup.3 R.sup.3 R.sup.1 =      OCH.sub.3, R.sup.2 = CO.sub.2 H S(CH.sub.3).sub.3 CH.sub.2 CO.sub.2      CH.sub.3 R.sup.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2      CH.sub.2 CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 S(C.sub.6 H.sub.5) CH.sub.2      CH.sub.2 CO.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 S(3CF.sub.3 C.sub.6      H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 (CH.sub.2).sub.4 CH.sub.3      S(2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 SCH.sub.2       CH.sub.3 (CH.sub.2)SCH.sub.3 S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.6 CH.sub.3 S(2,4ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 (CH.sub.2).sub.7      CH.sub.3 S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.8      CH.sub.3 2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2      (CH.sub.2).sub.9 CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2       CHCHCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 CH(CH.sub.3 ).sub.2      NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl      CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5 CH.sub.2 CH.sub.2       CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 NHCH.sub.2 (C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4 CH.sub.2      CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.3 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3 NHCH.sub.2 (4CH.sub.3      C.sub.6 H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.2 CH.sub.3 NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6      H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.3 NHCH.sub.2      (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2      NHCH.sub.2 CH.sub.3 NH(C.sub.6 H.sub.5) 2SCH.sub.3 C.sub.6 H.sub.4      CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2 NH(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2 CH.sub.3      NH(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      -cyclopropyl NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4)      CH.sub.2 -cyclobutyl NH(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6      H.sub.4) CH.sub.2 -cyclopentyl NH(2,6ClC.sub.6 H.sub.3) CH.sub.2      (2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclohexyl N(CH.sub.3)(3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) cyclopropyl      N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3 C.sub.6      H.sub.4) cyclobutyl N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6 H.sub.4)      cyclopentyl N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3) cyclohexyl      N(CH.sub.2).sub.6 CH.sub.2 (2,6ClC.sub.6 H.sub.3) CH.sub.2 OCH.sub.2      CH.sub.3 N(CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2       (3,4FC.sub.6 H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 R.sup.3      R.sup.3 R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3 CH.sub.2 OCH.sub.2 (C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 SCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6 H.sub.5) CH.sub.2      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) S(2ClC.sub.6      H.sub.4) CH.sub.2 OCH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2     C      (2Cl.sub.6 H.sub.4) S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 OCH.sub.2      (2,4FC.sub.6 H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5) S(2,4ClC.sub.6      H.sub.3) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2       NH(2ClC.sub.6 H.sub.4) S(2,6FC.sub.6 H.sub.3) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C.sub.6      H.sub.4) CH.sub.2 O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 CH.sub.2      CH.sub.3 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 O(4CF.sub.3 C.sub.6      H.sub.4) OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2 (CH.sub.2).sub.3      CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 O(3SCH.sub.3      C.sub.6 H.sub.4) OCH.sub. 2 (CH.sub.2).sub.5 CH.sub.3 NHCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6       H.sub.4) OCH.sub.2 C(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      NHCH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 O(2,4ClC.sub.6 H.sub.3) OCH.sub.2      (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 SCH.sub.2 CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5)      NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) CH.sub.2      SCH.sub.2 (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) NHCH.sub.2       (2,6ClC.sub.6 H.sub.3) CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) CH.sub.2 S(2ClC.sub.6      H.sub.4) O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6      H.sub.4) CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3SCH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3)      CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3      NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2 (C.sub.6      H.sub.5) N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 S(3CF.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6       H.sub.4) N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6      H.sub.4) SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.2).sub.4      CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4)      N(CH.sub.2).sub.5 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2       (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6 CH.sub.2 S(2,4ClC.sub.6      H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) N(CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2).sub.2 R.sup.3 R.sup.1 = OCF.sub.3, R.sup.2 =      CO.sub.2 H R.sup.3 CH.sub.2 CO.sub.2 CH.sub.3 R.sup.3 CH.sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2       CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5)      CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2      CH.sub.3 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 CH.sub. 2 SCH.sub.2 CH.sub.3 (CH.sub.2).sub.5 CH.sub.3      CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2      NHCH.sub.2 CH.sub.3 (CH.sub.2).sub.6 CH.sub.3 CH.sub.2 OCH.sub.2      (4ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3      (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6 H.sub.3)      CHCH(CH.sub.3).sub.2 (CH.sub.2).sub.8 CH.sub.3 CH.sub.2 CH.sub.2      OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CHCH.sub.2        (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2      CHCHCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(3CF.sub.3 C.sub.6      H.sub.4) CHCHCH.sub.2 CH.sub.2 Cl CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl      CH.sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(2ClC.sub.6      H.sub.4) C.sub. 6 H.sub.5 CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4) 3CF.sub.3      C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      O(2CH.sub.3 C.sub.6 H.sub.4) 2ClC.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.2      CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2 O(4ClC.sub.6 H.sub.4) 3CH.sub.3      C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2      O(2,4ClC.sub.6 H.sub.3) 3OCH.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2      CH.sub.2 CH.sub.2 OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 2CF.sub.3      C.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2      SCH.sub.2 CH.sub.2 CH.sub.3 2,4ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2      CH.sub.2 CH.sub.2 SCH.sub.3 CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 2,6ClC.sub.6 H.sub.3 CH.sub.2 CH.sub.2 CH.sub.2       NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2 (C.sub.6 H.sub.5) 2SCH.sub.3      C.sub.6 H.sub.4 CH.sub.2 CF.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 CH.sub.2      CH.sub.2 CF.sub.2 CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 -cyclopropyl CH.sub.2 S(4CH.sub.3      C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 -cyclobutyl      CH.sub.2 S(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2      -cyclopentyl CH.sub.2 S(3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2       (2,4ClC.sub.6 H.sub.3) CH.sub.2 -cyclohexyl CH.sub.2 S(2,6ClC.sub.6      H.sub.3) CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) cyclopropyl CH.sub.2      S(C.sub.6 H.sub.5) CH.sub.2 (3OCH.sub.3 C.sub.6 H.sub.4) cyclobutyl      CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3ClC.sub.6 H.sub.4)      cyclopentyl CH.sub.2 S(2ClC.sub.6 H.sub.4 ) CH.sub.2 (2,6FC.sub.6      H.sub.3) cyclohexyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) CH.sub.2       C      (2,6Cl.sub.6 H.sub.3) CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2       S(2,6ClC.sub.6 H.sub.3) CH.sub.2 (3,4FC.sub.6 H.sub.3) CH.sub.2      OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 S(2,4ClC.sub.6 H.sub.3) R.sup.3      R.sup.3 R.sup.3 CH.sub.2 NHCH.sub.2 CH.sub.3 S(CH.sub.3).sub.3 CH.sub.2      CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 SCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      NHCH.sub.2 C(C.sub.6 H.sub.5) S(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2      CO.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 S(3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2       NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) S(2ClC.sub.6 H.sub.4) CH.sub.2      CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 NHCH.sub.2 (2ClC.sub. 6 H.sub.4)      S(4OCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3      CH.sub.2 NH(C.sub.6 H.sub.5) S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2      N(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6       H.sub.4) S(2,6FC.sub.6 H.sub.3) CHCH(CH.sub.3).sub.2 CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) 2(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CHCH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 NHCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 CHCHCH.sub.3 OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3      NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CHCHCH.sub.2 CH.sub.2 Cl OCH.sub.2      (CH.sub.2).sub.3 CH.sub.3 NHCH.sub.2 (CH.sub.2).sub.4 CH.sub.3 CH.sub.2      CH.sub.2 CHClCH.sub.2 Cl OCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NHCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5 OCH.sub.2 C(C.sub.6 H.sub.5)      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub. 6 H.sub.4 OCH.sub.2      (3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2 (C.sub.6 H.sub.5) 2ClC.sub.6      H.sub.4 OCH.sub.2 (2ClC.sub.6 H.sub.4) NHCH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) 3CH.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6      H.sub.4 O(C.sub.6 H.sub.5) NHCH.sub.2 (4CH.sub.3 C.sub.6 H.sub.4)      2CF.sub.3 C.sub.6 H.sub.4 O(3CF.sub.3 C.sub.6 H.sub.4) NHCH.sub.2      (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6 H.sub.3 O(2ClC.sub.6 H.sub.4)      NHCH.sub.2 (2,6ClC.sub.6 H.sub.3) 2,6ClC.sub.6 H.sub.3 O(4SCH.sub.3      C.sub.6 H.sub.4) NH(C.sub.6 H.sub.5) 2SCH.sub.3 C.sub.6       H.sub.4 O(2,4ClC.sub.6 H.sub.3) NH(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      (C.sub.6 H.sub.5) SCH.sub.2 CH.sub.2 CH.sub.3 NH(2ClC.sub.6 H.sub.4)      CH.sub.2 (3CF.sub.3  C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.2      CH.sub.3 NH(3CH.sub.3 C.sub.6 H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4)      SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 NH(2,4ClC.sub.6 H.sub.3) CH.sub.2      (4ClC.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 NH(2,6ClC.sub.6      H.sub.3) CH.sub.2 (2,4ClC.sub.6 H.sub.3) SCH.sub.2 (C.sub.6 H.sub.5)      N(CH.sub.3)(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 (3SCH.sub.3 C.sub.6      H.sub.4) SCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3 C.sub.6 H.sub.4) SCH.sub.2      (2OCH.sub.3 C.sub.6 H.sub.4) N(CH.sub.2).sub.4 CH.sub.2 (3ClC.sub.6      H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) N(CH.sub.2).sub.5 CH.sub.2      (2,6FC.sub.6 H.sub.3) SCH.sub.2 (2,4-C.sub.6 H.sub.3) N(CH.sub.2).sub.6      CH.sub.2 (2,6ClC.sub.6 H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4)      N(CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6      H.sub.3) R.sup.1 = OCF.sub.2 H, R.sup.2 = CO.sub.2 H R.sup.3 R.sup.3      R.sup.3 CH.sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH.sub.3 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 OCH.sub.2 (C.sub.6 H.sub.5)      CH.sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 C(C.sub.6      H.sub.5) (CH.sub.2).sub.4 CH.sub.3 CH.sub.2 OCH.sub.2 (2ClC.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.5      CH.sub.3 CH.sub.2 OCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2      NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) (CH.sub.2).sub.6 CH.sub.3      CH.sub.2 OCH.sub.2 (4ClC.sub.6 H.sub.4) CH.sub.2 NHCH.sub.2 (2ClC.sub.6      H.sub.4)  (CH.sub.2).sub.7 CH.sub.3 CH.sub.2 OCH.sub.2 (2,4FC.sub.6      H.sub.3) CH.sub.2 NH(C.sub.6 H.sub.5) (CH.sub.2).sub.8 CH.sub.3 CH.sub.2      CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 NH(2ClC.sub.6 H.sub.4)      (CH.sub.2).sub.9 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       N(CH.sub.3)(2ClC.sub.6 H.sub.4) CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(3CF.sub.3 C.sub.6 H.sub.4) OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(4CF.sub.3 C.sub.6 H.sub.4)      OCH.sub.2 (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(2ClC.sub.6 H.sub.4) OCH.sub.2       (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.2 CH.sub.3 CH.sub.2 O(3SCH.sub.3 C.sub.6 H.sub.4) OCH.sub.2      (CH.sub.2).sub.5 CH.sub.3 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 O(2CH.sub.3 C.sub.6 H.sub. 4) OCH.sub.2 C(C.sub.6      H.sub.5) CH.sub.2 CH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.2      O(4ClC.sub.6 H.sub.4) OCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 CH.sub.2 O(2,4ClC.sub.6 H.sub.3)      OCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      OCH.sub.3 CH.sub.2 SCH.sub.2 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      CH.sub.2 CH.sub.3 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      SCH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 O(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 SCH.sub.2      (C.sub.6 H.sub.5) O(2ClC.sub.6 H.sub.4) CH.sub.2 CF.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4)      O(4SCH.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.2      CH.sub.3 CH.sub.2 S(2ClC.sub.6 H.sub.4) O(2,4ClC.sub.6 H.sub.3) CH.sub.2      -cyclopropyl CH.sub.2 S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.2 -cyclobutyl CH.sub.2 S(2,4ClC.sub.6 H.sub.3) SCH.sub.2      (CH.sub.2).sub.2 CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 S(3SCH.sub.3      C.sub.6 H.sub.4) SCH.sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       -cyclohexyl CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2       (CH.sub.2)SCH.sub.3 cyclopropyl CH.sub.2 S(C.sub.6 H.sub.5) SCH.sub.2      (C.sub.6 H.sub.5) cyclobutyl CH.sub.2 S(3CF.sub.3 C.sub.6 H.sub.4)      SCH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) cyclopentyl CH.sub.2 S(2ClC.sub.6      H.sub.4) SCH.sub.2 (2OCH.sub.3 C.sub.6 H.sub.4) cyclohexyl CH.sub.2      S(4CH.sub.3 C.sub.6 H.sub.4) SCH.sub.2 (2ClC.sub.6 H.sub.4) CH.sub.2      OCH.sub.2 CH.sub.3 CH.sub.2 S(2,6ClC.sub.6 H.sub.3) SCH.sub.2       (2,4-C.sub.6 H.sub.3)  CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2      S(2,4ClC.sub.6 H.sub.3) SCH.sub.2 (4CF.sub.3 C.sub.6 H.sub.4) R.sup.3      R.sup.3 R.sup.1 = Cl, R.sup.2 = CO.sub.2 CH.sub.3 S(CH.sub.3).sub.3      CH.sub.2 CO.sub.2 CH.sub.3 R.sup.3 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 S(C.sub.6      H.sub.5) CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2      S(3CF.sub.3 C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 S(2ClC.sub.6 H.sub.4) CH.sub.2      CH.sub.2 SCH.sub.2 CH.sub.3 CH.sub.2 -cyclopentyl S(4OCH.sub.3 C.sub.6      H.sub.4) CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.3 CH.sub.2 O(C.sub.6      H.sub.5) S(2,4ClC.sub.6 H.sub.3) CH.sub.2 CH.sub.2 N(CH.sub.3)CH.sub.2      CH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 S(2,6FC.sub.6 H.sub. 3)      CHCH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 2(3CH.sub.3      C.sub.6 H.sub.4) CH.sub.2 CH.sub.2 CHCH.sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CHCHCH.sub.3      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (CH.sub.2).sub.2 CH.sub.3      CHCHCH.sub.2 CH.sub.2 Cl C.sub.6 H.sub.5 NHCH.sub.2 (CH.sub.2).sub.4      CH.sub.3 CH.sub.2 CH.sub.2 CHClCH.sub.2 Cl 3CF.sub.3 C.sub.6 H.sub.4      NHCH.sub.2 (CH.sub.2).sub.5 CH.sub.3 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2      (C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4 R.sup.1 = Br, R.sup.2 = CO.sub.2      CH.sub.3 NHCH.sub.2 (3CF.sub.3 C.sub.6 H.sub.4) 3CH.sub.3 C.sub.6      H.sub.4 R.sup.3 NHCH.sub.2 (2ClC.sub.6 H.sub.4) 3OCH.sub.3 C.sub.6      H.sub.4 (CH.sub.2 ).sub.3 CH.sub.3 NHCH.sub.2 (4CH.sub.3 C.sub.6      H.sub.4) 2CF.sub.3 C.sub.6 H.sub.4 CH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 (2,4ClC.sub.6 H.sub.3) 2,4ClC.sub.6      H.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 (2,6ClC.sub.6      H.sub.3) 2,6ClC.sub.6 H.sub.3 CH.sub.2 -cyclopentyl NH(C.sub.6 H.sub.5)      2SCH.sub.3 C.sub.6 H.sub.4 CH.sub.2 O(C.sub.6 H.sub.5) NH(3CF.sub.3      C.sub.6 H.sub.4) CH.sub.2 (C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 NH(2ClC.sub.6 H.sub.4) CH.sub.2 (3CF.sub.3 C.sub.6      H.sub.4) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NH(3CH.sub.3 C.sub.6      H.sub.4) CH.sub.2 (2ClC.sub.6 H.sub.4) OCH.sub.2 CH(CH.sub.3).sub.2      NH(2,4ClC.sub.6 H.sub.3) CH.sub.2 (4ClC.sub.6 H.sub.4) NHCH.sub.2      CH(CH.sub.3).sub.2 NH(2,6ClC.sub.6 H.sub.3) CH.sub.2 (2,4ClC.sub.6      H.sub.3) C.sub.6 H.sub.5 N(CH.sub. 3)(3CF.sub.3 C.sub.6 H.sub.4)      CH.sub.2 (3SCH.sub.3 C.sub.6 H.sub.4) 3CF.sub.3 C.sub.6       H.sub.4 N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 (3OCH.sub.3      C.sub.6 H.sub.4) 2ClC.sub.6 H.sub.4 N(CH.sub.2).sub.4 CH.sub.2       (3ClC.sub.6 H.sub.4) N(CH.sub.2).sub.5 CH.sub.2 (2,6FC.sub.6 H.sub.3)      R.sup.1 = I, R.sup.2 = CO.sub.2 CH.sub.3 N(CH.sub.2).sub.6 CH.sub.2      (2,6ClC.sub.6 H.sub.3) R.sup.3 N(CH.sub.2 CH.sub.2 OCH.sub.2       CH.sub.2).sub.2 CH.sub.2 (3,4FC.sub.6 H.sub.3) (CH.sub.2).sub.3      CH.sub.3 R.sup.3 R.sup.3 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4 NHCH.sub.2      CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5 2ClC.sub.6      H.sub.4 R.sup.1 = Br, R.sup.2 = CO.sub.2 CH.sub.2 CH.sub.3 3CF.sub.3      C.sub.6 H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = OCF.sub.2 H,      R.sup.2 = CO.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3  R.sup.3 CH.sub.2      CH(CH.sub.3).sub.2 R.sup.1 = OCH.sub.3, R.sup.2 = O.sub.2 CH.sub.3      (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup. 3      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6      H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6      H.sub.5 2ClC.sub.6 H.sub.4 R.sup.1 = I, R.sup.2 = CO.sub.2 CH.sub.2      CH.sub.3 3CF.sub.3 C.sub.6 H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 =      Cl, R.sup.2 = CO.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3      R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCF.sub.3, R.sup.2 =      CO.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 R.sup.3      OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6       H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub. 6 H.sub.4      C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4 R.sup.1 = Br, R.sup.2 = CHO 3CF.sub.3 C      .sub.6 H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = OCF.sub.2 H,      R.sup.2 = CO.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3  R.sup.3      CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCH.sub.3, R.sup.2 = CO.sub.2 l      CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5  CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5  2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      2ClC.sub.6 H.sub.4 R.sup.1 = I, R.sup.2 = CHO 3CF.sub.3 C.sub.6 H.sub.4      R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = Cl, R.sup.2 = CHO (CH.sub.2).sub.3      CH.sub.3  R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCF.sub.3,      R.sup.2 = CO.sub.2 CH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 R.sup. 3 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 R.sup.1 =      OCH.sub.3, R.sup.2 = CHO R.sup.3 R.sup. 3 R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      2ClC.sub.6 H.sub.4 R.sup.1 =  I, R.sup.2 = CCH 3CF.sub.3 C.sub.6 H.sub.4       R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = Cl, R.sup.2 = CCH (CH.sub.2).sub.3      CH.sub.3  R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCF.sub.3,      R.sup.2 = CHO (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5 ) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      2ClC.sub.6 H.sub.4 R.sup.1 = OCH.sub.3, R.sup.2 = CCH 3CF.sub.3 C.sub.6      H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = Br, R.sup.2 =       CCH (CH.sub.2).sub.3 CH.sub.3  R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.1 = OCF.sub.2 H, R.sup.2 = CHO (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub. 3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) R.sup.3 R.sup.3 R.sup.3      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4 NHCH.sub.2      CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5 2ClC.sub.6      H.sub.4 R.sup.1 = I, R.sup.2 = CNOH 3CF.sub.3 C.sub.6 H.sub.4  R.sup.3      2ClC.sub.6 H.sub.4 R.sup.1 = Cl, R.sup.2 = CHNOH (CH.sub.2).sub.3      CH.sub.3  R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCF.sub.3,      R.sup.2 = C CH (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub. 2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      2ClC.sub.6 H.sub.4 R.sup.1 = OCH.sub.3, R.sup.2 = CHNOH 3CF.sub.3      C.sub.6 H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 32  Br, R.sup.2      =CHNOH (CH.sub.2).sub.3 CH.sub.3  R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.1 = OCF.sub.2 H, R.sup.2 = CCH (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 R.sup.3 R.sup.1 = Cl, R.sup.2 = CHNOCH.sub.3 R.sup.3 2ClC.sub.6      H.sub.4 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2  (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCF.sub.3, R.sup.2 =      CHNOH CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl R.sup.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentyl CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      OCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2      CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 R.sup.1 = OCH.sub.3, R.sup.2 =      CHNOCH.sub.3 C.sub.6 H.sub.5  R.sup.3 3CF.sub.3 C.sub.6 H.sub.4 R.sup.1      = Br, R.sup.2 = CHNOCH.sub.3 (CH.sub.2).sub.3 CH.sub.3 2ClC.sub.6      H.sub.4 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2  (CH.sub. 2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCF.sub.2 H, R.sup.2 =    O      CHNH CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl R.sup.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentyl CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      OCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2      CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 R.sup.1 = OCF.sub.3, R.sup.2 =      CHNOCH.sub.3 C.sub.6 H.sub.5  R.sup.3 3CF.sub.3 C.sub.6 H.sub.4 R.sup.1      = I, R.sup.2 = CHNOCH.sub.3 (CH.sub.2).sub.3 CH.sub.3 2ClC.sub.6 H.sub.4      R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2  (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 R.sup.3 CH.sub.2       -cyclopentyl CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6      H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6      H.sub.5 2ClC.sub.6 H.sub.4 R.sup.1 = OCH.sub.3, 3CF.sub.3 C.sub.6      H.sub.4  R.sub.2 = CHNOCH.sub.2 CH.sub.3 2ClC.sub.6 H.sub.4 R.sup.1 =      Br, R.sup.2 = CHNOCH.sub.2 CH.sub.3 R.sup.3  R.sup.3 (CH.sub.2).sub.3      CH.sub.3 R.sup.1 = OCF.sub.2 H, R.sup.2 = CHNOCH.sub.3 (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 -cyclopentyl CH.sub.2       SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4      R.sup.1 = OCF.sub.3, 2ClC.sub.6 H.sub.4 R.sup.1 = I, R.sup.2 =       CHNOCH.sub.2 CH.sub.3 R.sup.2 = CHNOCH.sub.2 CH.sub.3  R.sup.3 R.sup.3      R.sup.1 = Cl, R.sup.2 = CHNOCH.sub. CH.sub.3 (CH.sub. 2).sub.3 CH.sub.3      (CH.sub.2).sub.3 CH.sub.3 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2  OCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 R.sup.3      NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 R.sup.1 = OCH.sub.3, R.sup.2 = CH.sub.2 OH 2ClC.sub.6 H.sub.4      R.sup.3  R.sup.1 = Br, R.sup.2 = CH.sub.2 OH (CH.sub.2).sub.3 CH.sub.3      R.sup.1 = OCF.sub.2 H, R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.2 =      CHNOCH.sub.2 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub. 2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      2ClC.sub.6 H.sub.4 R.sup.1 = OCF.sub.3, R.sup.2 = CH.sub.2 OH 3CF.sub.3      C.sub.6 H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = I, R.sup.2 =      CH.sub.2 OH (CH.sub.2).sub.3 CH.sub.3  R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.1 = Cl, R.sup.2 = CH.sub.2 OH (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 R.sup.1 =      OCF.sub.2 H, R.sup.2 = CH.sub.2 OH R.sup.3 R.sup.3 R.sup.3 2ClC.sub.6      H.sub.4 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 -cyclopentyl CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = Br, CH.sub.2      O(C.sub.6 H.sub.5)   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentylCH.sub.2 O(C.sub.6 H.sub.5)CH.sub.2 SCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2      ##STR13##       CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5   OCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 3CF.sub.3 C.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 2ClC.sub.6      H.sub.4 C.sub.6 H.sub.5 CH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCH.sub.3,      2ClC.sub.6 H.sub.4 CH.sub.2 -cyclopentyl   R.sup.1 = Cl, CH.sub.2      O(C.sub.6       H.sub.5)      ##STR14##       ##STR15##       CH.sub.2 SCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH (CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 R.sup.3      (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2        R.sup.3 2ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.3 CH.sub.3  CH.sub.2 -cyclopentyl CH.sub.2       CH(CH.sub.3).sub.2 R.sup.1 = I, CH.sub.2 O(C.sub.6 H.sub.5)   CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6      H.sub.5)CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2       ##STR16##       CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5   OCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 3CF.sub.3 C.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 2ClC.sub.6      H.sub.4 C.sub.6 H.sub.5  CH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 R.sup.1 = OCF.sub.3, R.sup.3 R.sup.3       ##STR17##       CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2       OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopent ylCH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2   R.sup.3 2ClC.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3  NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = Cl, C.sub.6      H.sub.5   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentylCH.sub.2 O(C.sub.6       H.sub.5)      ##STR18##       3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 R.sup.3 R.sup.1 =  OCH.sub.3,   CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2      ##STR19##         C.sub.6 H.sub.5 CH.sub.2 -cyclopentyl R.sup.3 3CF.sub.3 C.sub.6      H.sub.4 CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3 CH.sub.3 2ClC.sub.6      H.sub.4 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.1 = OCF.sub.2 H, CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2       ##STR20##       OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 CH.sub.2       -cyclopentylCH.sub.2 O(C.sub.6 H.sub.5)CH.sub.2 SCH.sub.2       CH(CH.sub.3)2CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2  OCH.sub.2       CH(CH.sub.3).sub.2  NHCH.sub.2 (CH.sub.3).sub.2   R.sup.3 R.sup.1 = Br,      C.sub.6 H.sub.5   (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2      ##STR21##       3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2 -cyclopentyl      R.sup.3 CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3 CH.sub.3 R.sup.1 =      OCF.sub.3, R.sup.3 R.sup.3       ##STR22##       NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 N      HCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4      R.sup.3 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 (CH.sub.2).sub.3 CH.sub.3       CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2       ##STR23##       ##STR24##         CH.sub.2 -cyclopentyl R.sup.3 R.sup.3 CH.sub.2 O(C.sub.6 H.sub.5)      (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3 ).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2       -cyclopentyl NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 O(C.sub.6 H.sub.5) C.sub.6 H.sub.5 CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 3CF.sub.3 C.sub.6      H.sub.4 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2      OCH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCF.sub.3 H, NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2       ##STR25##       ##STR26##       C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 R.sup.1 =      OCH.sub.3,         R.sup.3 R.sup.3      ##STR27##         (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 R.sup.3 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 -cyclopentyl CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 O(C.sub.6      H.sub.5) OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2  OCH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 R.sup.3 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub. 6      H.sub.5) OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      C.sub.6 H.sub.5 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4      C.sub.6 H.sub.5 C.sub.6 H.sub.5  3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4 R.sup.1 = OCF.sub.3, 2ClC.sub.6 H.sub.4 2ClC.sub.6      H.sub.4       ##STR28##       ##STR29##       ##STR30##         R.sup.3 R.sup.3 R.sup.3 (CH.sub. 2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      C.sub.6 H.sub.5 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub. 3      C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 2ClC.sub.6 H.sub.4       ##STR31##       ##STR32##       ##STR33##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2       -cyclopentyl

       R.sup.3 R.sup.3 R.sup.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      C.sub.6 H.sub.5 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 2ClC.sub.6 H.sub.4       ##STR34##       ##STR35##       ##STR36##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3      ).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 C.sub.6 H.sub.5 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4       ##STR37##       ##STR38##       ##STR39##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl R.sup.3 R.sup.3 R.sup.3 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 C.sub.6 H.sub.5      C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 NHCH.sub.2      CH(CH.sub.3).sub.2       ##STR40##       ##STR41##       C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   R.sup.3       (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl R.sup.3 (CH.sub.2).sub.3      CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2      ##STR42##         CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2       -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub. 2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl C.sub.6 H.sub. OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 2ClC.sub.6 H.sub.4      C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2       ##STR43##       3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      R.sup.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2      ##STR44##       3CF.sub.3 C.sub.6 H.sub.4 2-ClC.sub.6 H.sub.4   CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 -cyclopentyl (CH.sub.2).sub.3      CH.sub.3  R.sup.1 = OCF.sub.2 H, R.sup.3       ##STR45##       ##STR46##       NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4        R.sup.3  2ClC.sub.6 H.sub.4 (CH.sub.2).sub.3 CH.sub.3 R.sup.3 CH.sub.2      CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 R.sup.1 = Br,    CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentylCH.sub.2 O(C.sub.6      H.sub.5)CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentylCH.sub.2      O(C.sub.6       H.sub.5)      ##STR47##         CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 C.sub.6 H.sub.5  NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4      C.sub.6 H.sub.5 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4      3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 -cyclopentyl  2-ClC.sub.6 H.sub. 4      CH.sub.2 O(C.sub.6 H.sub.5)       ##STR48##       R.sup.1 = Cl, CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2   R.sup.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2      ##STR49##       OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH (CH.sub.3).sub.2 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2       -cyclopentyl R.sup.3 CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3      CH.sub.3 R.sup.1 = I,   CH.sub.2 SCH.sub.2 CH(CH.sub. 3)2CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 C-H(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentylCH.sub.2 O(C.sub.6      H.sub.5)CH.sub.2 SCH.sub.2       CH(CH.sub.3)2      ##STR50##         3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 2ClC.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3      CH.sub.3 R.sup.3 R.sup.1 = OCF.sub.3, R.sup.3   CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentylCH.sub.2 O(C.sub.6       H.sub.5)      ##STR51##       OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2       SCH.sub.2 CH(CH.sub.3)2 R.sup.3   CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6       H.sub.4 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentylCH.sub.2 O(C.sub.6      H.sub.5)       ##STR52##         2ClC.sub.6 H.sub.4 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 R.sup.3  CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 R.sup.1 =      OCH.sub.3, OCH.sub. 2 CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2       ##STR53##       NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2      ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentylCH.sub.2 O(C.sub.6 H.sub.5)CH.sub.2 SCH.sub.2 CH(CH.sub.3)2        R.sup.3  CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3      CH.sub.3 R.sup.1 = OCF.sub.2 H, OCH.sub.2 CH(CH.sub.3).sub.2   CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentylCH.sub.2 O(C.sub.6       H.sub.5)      ##STR54##       NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2      ClC.sub.6 H.sub.4   CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 R.sup.3   CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl       ##STR55##         3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 O(C.sub.6 H.sub.5) R.sup.3      2ClC.sub.6 H.sub.4 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 (CH.sub.2).sub.3      CH.sub.3  CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 R.sup.1 = OCH.sub.3, R.sup.3   CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2  CH.sub.2 -cyclopentylCH.sub.2 O(C.sub.6      H.sub.5)CH.sub.2 SCH.sub.2       CH(CH.sub.3)2      ##STR56##       OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2       NHCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 OCH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.3 CH.sub.3 R.sup.1 = OCF.sub.2 H,   NHCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 C      H.sub.2 -cyclopentylCH.sub.2 O(C.sub.6       H.sub.5)      ##STR57##       ##STR58##       CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2   R.sup.3 3CF.sub.3 C.sub.6 H.sub.4      CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 2ClC.sub.6 H.sub.4      CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH(CH.sub.3).sub.2  CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 =      OCF.sub.3, CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2   CH.sub.2             C       -cyclopentylH.sub.2 O(C.sub.6 H.sub.5)CH.sub.2 SCH.sub.2       CH(CH.sub.3)2CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2      ##STR59##       OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4   OCH.sub.2 CH(CH.sub.3).sub.2      2ClC.sub.6 H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 C.sub.6 H.sub.5      (CH.sub.2).sub.3 CH.sub.3 R.sup.1 = Cl,   3CF.sub.3 C.sub.6 H.sub.4      2ClC.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentyl      ##STR60##          CH.sub.2 O(C.sub.6 H.sub.5) R.sup.3  CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 (CH.sub.2).sub.3 CH.sub.3  CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup. 3 R.sup.1 = I,      R.sup.3   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentylCH.sub.2 O(C.sub.6       H.sub.5)      ##STR61##       3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 R.sup.3 R.sup.1 = OCF.sub.3,   CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2      ##STR62##         C.sub.6 H.sub.5 CH.sub.2 -cyclopentyl R.sup.3 3CF.sub.3 C.sub.6      H.sub.4 CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3       CH.sub. 3 2ClC.sub.6 H.sub.4 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2      CH(CH.sub.3).sub.2  CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = Br, OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 -cyclopentyl       ##STR63##       NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 C      H.sub.2 O(C.sub.6 H.sub.5)CH.sub.2 SCH.sub.2 CH(CH.sub.3)2CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2   R.sup.3 2ClC.sub.6 H.sub.4 OCH.sub.2      CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3  NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.1 = OCH.sub.3,      C.sub.6 H.sub.5   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       -cyclopentylCH.sub.2 O(C.sub.6       H.sub.5 )      ##STR64##       3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 R.sup.3 R.sup.1 = OCF.sub.2 H,   CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2      ##STR65##         C.sub.6 H.sub.5 CH.sub.2 -cyclopentyl R.sup.3 3CF.sub.3 C.sub.6      H.sub.4 CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3 CH.sub.3 2ClC.sub.6      H.sub.4 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub. 2       CH(CH.sub.3).sub.2  OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)  C.sub.6      H.sub.5 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2  CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 R.sup.3 OCH.sub.2 CH(CH.sub.3).sub.2      OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 C.sub.6 H.sub.5 NHCH.sub.2       CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4      C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 3CF.sub.3 C.sub.6      H.sub.4   2ClC.sub.6 H.sub.4       ##STR66##       ##STR67##       R.sup.1 = OCF.sub.3,        R.sup.3 R.sup.3      ##STR68##         (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2      -cyclopentyl CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) OCH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3 ).sub.2 C.sub.6      H.sub.5 C.sub.6 H.sub.5 OCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2       CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 C.sub.6      H.sub.5   3CF.sub.3 C.sub.6 H.sub.4  R.sup.1 = OCH.sub.3, 2ClC.sub.6      H.sub.4       ##STR69##       ##STR70##       R.sup.1 = OCF.sub.2 H,   R.sup.3 R.sup.3   (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3       CH.sub.3      ##STR71##         CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 CH.sub.2 -cyclopentyl CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2 ).sub.3 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       -cyclopentyl CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 -cyclopentyl R.sup.3 R.sup.3 R.sup.3      CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      2ClC.sub.6 H.sub.4 R.sup.1 = OCF.sub.3, R.sup.2 = CHCH.sub.2 3CF.sub.3      C.sub.6 H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = I, R.sup.2 =      CHCH.sub.2 (CH.sub.2).sub.3 CH.sub.3  R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.1 = Cl, R.sup.2 = CHCH.sub.2 (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub. 2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6      H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      2ClC.sub.6 H.sub.4 R.sup.1 = OCF.sub.2 H, R.sup.2 = CHCH.sub.2 3CF.sub.3 C      .sub.6 H.sub.4  R.sup.3 2ClC.sub.6 H.sub.4 R.sup.1 = OCH.sub.3, R.sup.2      = CHCH.sub.2 (CH.sub.2).sub.3 CH.sub.3  R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 R.sup.1 = Br, R.sup.2 = CHCH.sub.2 (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 CH (CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 SCH.sub. 2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 R.sup.3 R.sup.3 R.sup.3 3CF.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      2ClC.sub.6 H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2       ##STR72##       C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5   R.sup.3 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2       CH(CH.sub.3).sub.2      ##STR73##       3CF.sub.3 C.sub.6 H.sub.4 2-ClC.sub.6 H.sub.4   CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentylCH.sub.2 O(C.sub.6 H.sub.5)      R.sup.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2      ##STR74##         CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      (CH.sub.2).sub.3 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl 3CF.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      2ClC.sub.6 H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2       ##STR75##       C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5   R.sup.3 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2       CH(CH.sub.3).sub.2      ##STR76##       3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentylCH.sub.2 O(C.sub.6 H.sub.5)      R.sup.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2      ##STR77##         CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      (CH.sub.2).sub.3 CH.sub.3        R.sup.3      ##STR78##       ##STR79##         CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 R.sup.3 CH.sub.2 -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 (CH.sub.      2).sub.3 CH.sub.3 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl CH.sub.2 -cyclopentyl OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4      OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6      H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2       ##STR80##       C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub. 4 2ClC.sub.6 H.sub.4 C.sub.6      H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   R.sup.3       (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2      ##STR81##       ##STR82##         CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 CH.sub.2      -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2       -cyclopentyl OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 O(C.sub.6 H.sub. 5) NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 C.sub.6 H.sub.5      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2  C.sub.6      H.sub.5 C.sub.6 H.sub.5  3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6      H.sub.4  2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4  R.sup.1 = Br, R.sup.1 =      OCH.sub.3,       ##STR83##       ##STR84##       ##STR85##         R.sup.3 (CH.sub.2).sub.3 CH.sub.3 R.sup.3 R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6       H.sub.5 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5  C.sub.6 H.sub.5 2ClC.sub.6      H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4  2ClC.sub.6      H.sub.4 2ClC.sub.6 H.sub.4 R.sup.1 = Cl, R.sup.1 = I, R.sup.1 =       OCF.sub.3,       ##STR86##       ##STR87##       ##STR88##         R.sup.3 (CH.sub.2).sub.3 CH.sub.3 R.sup.3 R.sup.3 CH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl CH.sub. 2 -cyclopentyl CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3      C.sub.6 H.sub.4 C.sub.6 H.sub.5 C.sub.6 H.sub.5 2ClC.sub.6 H.sub.4      3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4  2ClC.sub.6 H.sub.4      R.sup.3 R.sup.3 R.sup.3 2ClC.sub.6 H.sub.4 C.sub.6 H.sub.5 C.sub.6      H.sub.5  3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 R.sup.1 =      OCF.sub.2 H, 2ClC.sub.6 H.sub. 4 2ClC.sub.6 H.sub.4       ##STR89##       ##STR90##       ##STR91##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub.2 CH(CH.sub. 3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      C.sub.6 H.sub.5 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 2ClC.sub.6 H.sub.4       ##STR92##       ##STR93##       ##STR94##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub. 3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3      R.sup.3 C.sub.6 H.sub.5 C.sub.6 H.sub.5 NHCH.sub.2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 C.sub. 6 H.sub.5      2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4       ##STR95##       ##STR96##       2ClC.sub.6 H.sub.4 R.sup.1 = OCH.sub.3,   R.sup.3 (CH.sub.2).sub.3      CH.sub.3 R.sup.3 (CH.sub.2).sub.3       CH.sub.3      ##STR97##         CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 -cyclopentyl CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 C.sub.6 H.sub.5 OCH.sub.2       CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4      NHCH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4      C.sub.6 H.sub.5       ##STR98##       ##STR99##       3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   R.sup.3 R.sup.3 R.sup.1      = OCF.sub.3,   (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2      ##STR100##         CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl R.sup.3 CH.sub.2       O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) (CH.sub.2).sub.3      CH.sub.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2       CH(CH.sub.3)2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 O(C.sub.6 H.sub.5) R.sup.3 R.sup.3 R.sup.3 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 -cyclopentyl CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 -cyclopentyl OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 O(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      C.sub.6 H.sub.5 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4      C.sub.6 H.sub.5 NHCH.sub.2 CH(CH.sub.3).sub.2  3CF.sub.3 C.sub.6 H.sub.4      C.sub.6 H.sub.5 R.sup.1 = OCF.sub.2 H, 2ClC.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4       ##STR101##       ##STR102##        2ClC.sub.6 H.sub.4        R.sup.3      ##STR103##         (CH.sub.2).sub.3 CH.sub.3 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.3 CH.sub.3 R.sup.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       -cyclopentyl CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl CH.sub.2 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 O(C.sub.6      H.sub.5) OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 NHCH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2      CH(CH.sub. 3).sub.2 C.sub.6 H.sub.5 NHCH.sub.2 CH(CH.sub.3).sub.2      OCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5      NHCH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 3CF.sub.3 C.sub.6      H.sub.4 C.sub.6 H.sub.5  2ClC.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4       ##STR104##       ##STR105##       2ClC.sub.6 H.sub.4        R.sup.3      ##STR106##         (CH.sub.2).sub.3 CH.sub.3 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.3 CH.sub.3 R.sup.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3   R.sup. 3      CH.sub.2       CH(CH.sub.3).sub.2      ##STR107##       ##STR108##         CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 CH.sub.2      -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3      CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2       -cyclopentyl OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      CH.sub.2 O(C.sub.6 H.sub.5) NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 C.sub.6 H.sub.5      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3      ).sub.2 3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2  C.sub.6 H.sub.5 C.sub.6 H.sub.5 R.sup.1 =      OCF.sub.2 H, 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4       ##STR109##       2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4        R.sup.3      ##STR110##       ##STR111##         (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 (CH.sub.2).sub.3       CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 -cyclopentyl CH.sub.2      CH(CH.sub.3).sub.2 CH.sub. 2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2       -cyclopentyl CH.sub.2 -cyclopentyl CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      C.sub.6 H.sub.5 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4      C.sub.6 H.sub.5 C.sub.6 H.sub.5  3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4  2ClC.sub.6 H.sub.4 2ClC.sub.6       H.sub.4

      ##STR112##       ##STR113##       ##STR114##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub. 2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      C.sub.6 H.sub.5 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 2ClC.sub.6 H.sub.4       ##STR115##       ##STR116##       ##STR117##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2 ).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      C.sub.6 H.sub.5 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4  2ClC.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 2ClC.sub.6 H.sub.4       ##STR118##       R.sup.1 = Cl, R.sup.3        R.sup.3      ##STR119##       2ClC.sub.6 H.sub.4   (CH.sub.2).sub.3 CH.sub.3  R.sup.1 = I,   CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl R.sup.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2       ##STR120##         CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2       -cyclopentyl (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2       CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      -cyclopentyl C.sub.6 H.sub.5 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 2ClC.sub.6 H.sub.4      C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2  3CF.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2       ##STR121##       2ClC.sub.6 H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      R.sup.3 R.sup.1 = Br, 3CF.sub.3 C.sub.6 H.sub.4   (CH.sub.2).sub. 3      CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2      ##STR122##       2ClC.sub.6 H.sub.4   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2  R.sup.1 =      OCH.sub.3,   CH.sub.2 -cyclopentylCH.sub.2 O(C.sub.6 H.sub.5) R.sup.3      (CH.sub.2).sub.3 CH.sub.3 CH.sub.2       CH(CH.sub.3).sub.2      ##STR123##         CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      R.sup.3 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl      (CH.sub.2).sub.3 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       O(C.sub.6 H.sub.5) CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 CH.sub. 2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl 3CF.sub.3 C.sub.6 H.sub.4      OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) 2ClC.sub.6      H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2  3CF.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 R.sup.3 R.sup.3 R.sup.3      NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 C.sub.6 H.sub.5 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 3CF.sub.3      C.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 2ClC.sub.6 H.sub.4 NHCH.sub.2 CH(CH.sub.3).sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2  C.sub.6 H.sub.5 C.sub.6 H.sub.5 R.sup.1 =      OCF.sub.3, 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4       ##STR124##       2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4        R.sup.3      ##STR125##       ##STR126##         (CH.sub.2).sub.3 CH.sub.3 R.sup.3 R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 NHCH.sub.2 CH(CH.sub. 3).sub.2 CH.sub.2 SCH.sub.2      CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6       H.sub.5 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2      3CF.sub.3 C.sub.6 H.sub.4 C.sub.6 H.sub.5 C.sub.6 H.sub.5 2ClC.sub.6      H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 R.sup.1 =      OCF.sub.2 H, 2ClC.sub.6 H.sub.4 2ClC.sub.6 H.sub.4       ##STR127##       ##STR128##       ##STR129##         R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3 CH.sub.3      R.sup.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       CH(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 -cyclopentyl R.sup.3 R.sup.3 R.sup.1 = Br,   C      H.sub.2 O(C.sub.6 H.sub.5)CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2       CH(CH.sub.3).sub.2      ##STR130##         CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl R.sup.3      OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6       H.sub.5) (CH.sub.2).sub.3 CH.sub.3  NHCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH(CH.sub.3).sub.2 C.sub.6      H.sub.5 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 3CF.sub.3 C.sub.6 H.sub.4 OCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl 2ClC.sub.6 H.sub.4 NHCH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)  C.sub.6 H.sub.5 CH.sub.2      SCH.sub.2 CH(CH.sub.3)2 R.sup.1 = OCF.sub.3, 3CF.sub.3 C.sub.6 H.sub.4      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2       ##STR131##       2ClC.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2    R.sup.1 = Cl, C.sub.6 H.sub.5   R.sup.3       (CH.sub.2).sub.3       CH.sub.3      ##STR132##       3CF.sub. 3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4   CH.sub.2       CH(CH.sub.3).sub.2 R.sup.3 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2      (CH.sub.2).sub.3 CH.sub.3 R.sup.1 = I,   CH.sub.2 -cyclopentylCH.sub.2      O(C.sub.6 H.sub.5) CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2       ##STR133##         CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 -cyclopentyl R.sup.3      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 O(C.sub.6 H.sub.5)      (CH.sub.2).sub.3 CH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2       SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5 OCH.sub.2 CH(CH.sub.3).sub.2      CH.sub.2 -cyclopentyl 3CF.sub.3 C.sub.6 H.sub.4 NHCH.sub.2       CH(CH.sub.3).sub. 2 CH.sub.2 O(C.sub.6 H.sub.5) 2ClC.sub.6 H.sub.4      C.sub.6 H.sub.5 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 R.sup.1 = OCF.sub.2 H,      3CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2       ##STR134##       2ClC.sub.6 H.sub.4 OCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 C.sub.6 H.sub.5   R.sup.3  3CF.sub.3 C.sub.6 H.sub.4      (CH.sub.2).sub.3 CH.sub.3  2ClC.sub.6 H.sub.4 R.sup.1 = OCH.sub.3,      R.sup.1 = OCF.sub.3, R.sup.1 = OCF.sub.2 H,       ##STR135##       ##STR136##       ##STR137##         R.sup.3 R.sup.3 R.sup.3 (CH.sub.2).sub.3 CH.sub.3 (CH.sub.2).sub.3      CH.sub.3 (CH.sub.2).sub.3 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2      CH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 -cyclopentyl CH.sub.2 -cyclopentyl      CH.sub.2 -cyclopentyl CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 O(C.sub.6      H.sub.5) CH.sub.2 O(C.sub.6 H.sub.5) CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 SCH.sub.2 CH(CH.sub.3)2 CH.sub.2 SCH.sub.2 CH(CH.sub.3)2      CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2      CH(CH.sub.3).sub.2 OCH.sub.2 CH(CH.sub.3).sub.2 OCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 NHCH.sub.2       CH(CH.sub.3).sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2 C.sub.6 H.sub.5      C.sub.6 H.sub.5 C.sub.6 H.sub.5 3CF.sub.3 C.sub.6 H.sub.4 3CF.sub.3      C.sub.6 H.sub.4 3CF.sub.3 C.sub.6 H.sub.4 2ClC.sub.6 H.sub.4 2ClC.sub.6      H.sub.4 2ClC.sub.6       H.sub.4

                  TABLE 2                                                          ______________________________________                                          ##STR138##                                                                    R.sup.1 = Cl, R.sup.2 = CN                                                     R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Br, R.sup.2 = CN                                                     R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  R.sup.1 = OCF.sub.3, R.sup.2 = CN                                              R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub.2 H, R.sup.2 = CN                                            R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR139##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR140##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR141##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR142##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub. 6 H.sub.5)                                                   CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Cl, R.sup.2 = CCH                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Br, R.sup.2 = CCH                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub.3, R.sup.2 = CCH                                             R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub. 2 H, R.sup.2 = CCH                                          R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR143##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                   ##STR144##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                   ##STR145##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                   ##STR146##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR147##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                   ##STR148##                                                                    R.sup.3                                                                        (CH.sub.2 ).sub.3 CH.sub.3                                                     CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                   ##STR149##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR150##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR151##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR152##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR153##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR154##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR155##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub. 2 CH(CH.sub.3).sub.2                                                 C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR156##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR157##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR158##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Cl, R.sup.2 CH.sub.2 OH                                              R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub. 6 H.sub.5)                                                   CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Br, R.sup.2 CH.sub.2 OH                                              R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub.3, R.sup.2 CH.sub.2 OH                                       R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub. 2 -cyclopentyl                                                         CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub.2 H, R.sup.2 CH.sub.2 OH                                     R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR159##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub. 2                                                   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR160##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                   ##STR161##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub. 2                                                   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR162##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR163##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR164##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub. 4                                                      2ClC.sub.6 H.sub.4                                                              ##STR165##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR166##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub. 2 CH(CH.sub.3).sub.2                                        OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             ______________________________________                                    

                  TABLE 3                                                          ______________________________________                                                 ##STR167##                                                                    R.sup.1 = Cl, R.sup.2 = CN                                                     R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Br, R.sup.2 = CN                                                     R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub.3, R.sup.2 = CN                                              R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR168##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub. 3)2                                              CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR169##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR170##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR171##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR172##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub. 2 CH(CH.sub.3).sub.2                                                   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR173##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               CH.sub.2 NHCH.sub.2 CH(CH.sub.3).sub.2                                         OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR174##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR175##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR176##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Cl, R.sup.2 = CH.sub.2 OH                                            R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Br, R.sup.2 = CH.sub.2 OH                                            R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub.3, R.sup.2 = CH.sub.2 OH                                     R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR177##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub. 2 CH(CH.sub.3).sub.2                                                   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR178##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR179##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub. 2 CH(CH.sub.3).sub.2                                                   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR180##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR181##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR182##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR183##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR184##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR185##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Cl, R.sup.2 = CCH                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = Br, R.sup.2 = CCH                                                    R.sup. 3                                                                       (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                             R.sup.1 = OCF.sub.3, R.sup.2 = CCH                                             R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR186##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR187##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                              ##STR188##                                                                    R.sup.3                                                                        (CH.sub.2).sub.3 CH.sub.3                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                    CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                           CH.sub.2 -cyclopentyl                                                          CH.sub.2 O(C.sub.6 H.sub.5)                                                    CH.sub.2 SCH.sub.2 CH(CH.sub.3)2                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                   NHCH.sub.2 CH(CH.sub.3).sub.2                                                  C.sub.6 H.sub.5                                                                3CF.sub.3C.sub.6 H.sub.4                                                       2ClC.sub.6 H.sub.4                                                      ______________________________________                                    

Formulations

This invention can be conveniently carried out by formulating a compound of Formula I in the conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The herbicidal formulations of the invention comprise 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:

    ______________________________________                                                     Weight Percent*                                                                Active                                                                         Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             20-90      0-74     1-10                                         Oil Suspensions,                                                                              3-50     40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts          1-25     70-99     0-5                                          Granules and Pellets                                                                         0.1-95      5-99.9  0-15                                         High Strength 90-99      0-10     0-2                                          Compositions                                                                   ______________________________________                                          *Active ingredient plus at least one of a Surfactant or a Diluent equals       100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook or Insecticide Dust Diluents and Carriers", 2nd Ed Dorland Books, Caldwell, N.J., but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed, Interscience, N.Y., 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp 147ff and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.

For further information regarding the art of formulation, see for example:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, Jun. 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science:, John Wiley and Sons, Inc., New York, 1961, ppl 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

In the following Examples, all parts are by weight unless otherwise indicated.

EXAMPLE A

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                            50%                                                sodium alkylnaphthalenesulfonate                                                                            2%                                                low viscosity methyl cellulose                                                                              2%                                                diatomaceous earth          46%                                                ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.

EXAMPLE B

    ______________________________________                                         Granule                                                                        ______________________________________                                         Wettable Powder of Example A                                                                           5%                                                     attapulgite granules   95%                                                     (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                              ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE C

    ______________________________________                                         Extruded Pellet                                                                ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                            25%                                                anhydrous sodium sulfate    10%                                                crude calcium liginsulfonate                                                                                5%                                                sodium alkylnaphthalenesulfonate                                                                            1%                                                calcium/magnesium bentonite 59%                                                ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.

EXAMPLE D

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                           0.1%                                                attapulgite granule       99.9%                                                (U.S.S. 20-40 sieve)                                                           ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.

EXAMPLE E

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                             1%                                                N,N-dimethylformamide        9%                                                attapulgite granule         90%                                                (U.S.S. 20-40 sieve)                                                           ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.

EXAMPLE F

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                            40%                                                sodium ligninsulfonate      20%                                                montmorillonite clay        40%                                                ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.

EXAMPLE G

    ______________________________________                                         Emulsifiable Concentrate                                                       ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                            35%                                                blend of polyalcohol carboxylic                                                                             6%                                                esters and oil soluble petroleum sulfonates                                    xylene                      59%                                                ______________________________________                                    

The ingredients are combined and filtered to remove undissolved solids. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE H

    ______________________________________                                         Dust                                                                           ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                            10%                                                attapulgite                 10%                                                Pyrophyllite                80%                                                ______________________________________                                    

The active ingredient is blended with attapulgite and then passed thorugh a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.

EXAMPLE I

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                            20%                                                sodium alkylnaphthalenesulfonate                                                                            4%                                                sodium ligninsulfonate       4%                                                low viscosity methyl cellulose                                                                              3%                                                attapulgite granule         69%                                                ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.

EXAMPLE J

    ______________________________________                                         2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide                                                          48.8%                                                Altox ® 3404F - anionic/nonionic emulsifier                                                           2.4%                                                Altox ® 3455F - anionic/nonionic emulsifier                                                           5.6%                                                Aromatic 100 (Exxon) - xylene range solvent                                                              43.2%                                                ______________________________________                                    

The composition was prepared by mixing the ingredients together in a suitable vessel until complete dissolution of all the components occurred.

UTILITY

Test results indicate that the compositions of this invention include active postemergence and preemergence herbicides. The compositions of this invention are particularly useful for the control of barnyardgrass (Echinocloa crus-galli) in crops and especially in upland and paddy rice (Oryza sativa).

Effective rates of application for the compositions of this invention are determined by a number of factors. These factors include: formulation selected, method of application, amount and type of vegetation present, growing conditions, etc. In general terms, the compositions of the invention should be applied at rates which would involve from 0.005 to 10 kg/ha of the active compound of the composition with a preferred rate range of 0.01 to 1 kg/ha. One skilled in the art can easily determine effective application rates necessary for desired level of weed control.

The compositions of this invention may also include, in combination, other commercial herbicides, insecticides, or fungicides. The following list exemplifies some of the herbicides suitable for use in mixtures. A combination of a compound from the present composition with one or more of the following herbicides may be particularly useful for weed control in rice.

    ______________________________________                                         Common Name  Chemical Name                                                     ______________________________________                                         acetochlor   2-chloro-N-(ethoxymethyl)N-(2-ethyl-                                           6-methylphenyl)acetamide                                          alachlor     2-chloro-N-(2,6-diethylphenyl)-N-                                              (methoxymethyl)acetamide                                          bensulfuron  2-[[[[[(4,6-dimethoxy-2-pyrimidinyl)                                           amino]methylcarbonyl]amino]-                                                   sulfonyl]methyl]benzoic acid,                                                  methyl ester                                                      bentazon     3-(1-methylethyl)-(1H)-2,1,3-benzo-                                            thiadiazin-4(3H)-one, 2,2-dioxide                                 bifenox      methyl 5-(2,4-dichlorophenoxy)-2-                                              nitrobenzoate                                                     bromobutide  (+)2-bromo-3,3-dimethyl-N-(1-methyl-                                           1-phenylethyl)butanamide                                          butachlor    N-(butoxymethyl)-2-chloro-N-(2,6-                                              diethylphenyl)acetamide                                           CGA142464    N-[2-(2-methoxyethoxy-phenyl                                                   sulfonyl]-N'-4,6-dimethoxy-1,3,5-                                              triazin-2-yl urea                                                 chlorimuron  2-[[[[(4,chloro-6-methoxy-2-pyrimi-                                            dinyl)ethylamino]carbonyl]amino]-                                              sulfonyl]benzoic acid, ethyl ester                                chlornitrofen                                                                               1,3,5-trichloro-2-(4-nitrophenoxy)-                                            benzene                                                           chlorsulfuron                                                                               2-chloro-N-[[(4-methoxy-6-methyl-                                              1,3,5-triazin-2-yl)amino]carbonyl]-                                            benzenesulfonamide                                                chlortoluron N'-(3-chloro-4-methylphenyl)-N,N-                                              dimethylurea                                                      cinmethylin  exo-1-methyl-4-(1-methylethyl)-2-[(2-                                          methylphenyl)methoxy]-7-oxabicyclo-                                            [2.2.1]heptane                                                    cyperquat    1-methyl-4-phenylpyridinium                                       cyprazine    2-chloro-4-(cyclopropylamino)-6-(iso-                                          propylamino)- .sub.- s-triazine                                   dithiopyr    s,s-dimethyl-2-(difluoromethyl)-4-(z-                                          methylpropyl)-6-(trifluoromethyl)-                                             3,5-pyridinedicarbothionate                                       DPX A8947    N-[[(4,6-dimethoxypyrimidin-2-yl)-                                             amino]carbonyl]-1-methyl-4-(2-                                                 methyl-2H-tetrazol-5-yl)-1H-                                                   pyrazole-5-sulfonamide                                            endothall    7-oxabicyclo[2.2.1]heptane-2,3-                                                dicarboxylic acid                                                 esprocarb    s-(phenylmethyl)(1,2-dimethylpropyl)                                           ethylcarbamothioate                                               isoproturon  N-(4-isopropylphenyl)-N',N'-dimethyl-                                          urea                                                              MCPA         (4-chloro-2-methylphenoxy)acetic acid                             mefenacet    2-(2-benzothiazolyloxy)-N-methyl-N-                                            phenyl acetamide                                                  metsulfuron methyl                                                                          2-[[[[(4-methoxy-6-methyl-1,3,5-                                               triazin-2-yl)amino]carbonyl]-                                                  amino]sulfonyl]benzoic acid, methyl                                            ester                                                             molinate     S-ethyl hexahydro-1H-azepine-1-carbo-                                          thioate                                                           MY-93        1-piperidinecarbothioic acid,s-/1-                                             methyl-1-phenyl ethyl/ester                                       NSK 850      2-chloro-N-(2,6-dimethylphenyl)-N-                                             (((3-methoxy-2-thienyl)methyl))-                                               acetamide                                                         oxadiazon    3-[2,4-dichloro-5-(1-methylethoxy)-                                            phenyl]-5-(1,1-dimethylethyl)-                                                 1,3,4-oxadiazol-2(3H)-one                                         oxyfluorfen  2-chloro-1-(3-ethoxy-4-nitrophenoxy)-                                          4-(trofluoromethyl)benzene                                        pretilachlor 2-chloro-N-(2,6-diethylphenyl)-N-(2-                                           propoxyethyl)acetamide                                            propanil     N-(3,4-dichlorophenyl)propanamide                                 pyrazolate   4-(2,4-dichloro benzoyl)-1,3-                                                  dimethylpyrazol-5-yl-p-toluene-                                                sulphonate                                                        pyrazosulfuron-                                                                             ethyl 5-[[[[(4,6-dimethoxy-2-                                     ethyl        pyrimidinyl)amino]carbonyl]-                                                   amino]sulfonyl]-1-methyl-1H-                                                   pyrazole-4-carboxylate                                            quinclorac   3,7-dichloro-8-quinolinecarboxylic                                             acid                                                              thifensulfuron                                                                              3-[[[[(4-methoxy-6-methyl-1,3,5-                                               triazin-2-yl)amino]carbonyl]amino]-                                            sulfonyl]-2-thiophenecarboxylic                                                acid, methyl ester                                                thiameturon- methyl 3-[[[[(4-methoxy-6-methyl-                                 methyl       1,3,5-triazin-2-yl)amino]carbonyl]-                                            amino]sulfonyl]2-thiophene-                                                    carboxylate                                                       thiobencarb  S-[(4-chlorophenyl)methyl) diethyl-                                            carbamothioate                                                    tiocarbazil  S-(phenylmethyl)bis(1-methylpropyl)-                                           carbamothioate                                                    trisulfuron  2-(2-chloroethoxy)-N-[[(4-methoxy-6-                                           methyl-1,3,5-triazin-2-yl)amino]-                                              carbonyl]benzenesulfonamide                                       tribenuron methyl                                                                           2-[[[[N-(4-methoxy-6-methyl-1,3,5-                                             triazine-2-yl)-N-methylamino]-                                                 carbonyl]amino]sulfonyl] benzoic                                               acid, methyl ester                                                2,4-D        (2,4-dichlorophenoxy)acetic acid                                  ______________________________________                                    

Selective herbicidal properties of the subject compounds were discovered in greenhouse tests as described below.

                                      TABLE 4                                      __________________________________________________________________________     CMPD                                                                               R.sup.1                                                                            R.sup.2     R.sup.3        mp (°C.)                             __________________________________________________________________________      1  Cl  CN          C.sub.6 H.sub.5                                                                               135-136                                      2  Cl  CO.sub.2 CH.sub.3                                                                          CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                          3  Cl  C(O)NH.sub.2                                                                               CH.sub.2 CH(CH.sub.3).sub.2                                                                   110-118                                      5  OCH.sub.3                                                                          CN          CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                          6  Cl  CN          CH.sub.2 -cyclopentyl                                                                         65-68                                        7  Cl                                                                                  ##STR189## CH.sub.2 CH(CH.sub.3).sub.2                                                                   75-76                                        8  Cl  CN          CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          30-31                                        9  Cl  C(O)NH.sub.2                                                                               C.sub.6 H.sub.5                                                                               176-178                                     10  Cl  C N         CH.sub.2C.sub.6 H.sub.5                                                                       oil                                         11  Cl  C(O)NH.sub.2                                                                               CH.sub.2 -cyclopentyl                                                                         120-121                                     12  Cl  CN          3CF.sub.3 C.sub.6 H.sub.4                                                                     105-108                                     13  Cl  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          119-120                                     14  Cl  C(O)NH.sub.2                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                      95-98                                       15  Cl  C(O)NH.sub.2                                                                               3CF.sub.3 C.sub.6 H.sub.4                                                                     109-112                                     16  OCH.sub.3                                                                          CN          CH.sub.2 C.sub.6 H.sub.5                                                                      117-121                                     17  OCH.sub.3                                                                          C(O)NH.sub.2                                                                               3CF.sub.3 C.sub.6 H.sub.4                                                                     174-176                                     18  Cl  CO.sub.2 H  CH.sub.2 CH(CH.sub.3).sub.2                                                                   75-80                                       19  Br  CN          CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                         20  Cl  CN          CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                           oil                                         21  Br  C(O)NH.sub.2                                                                               CH.sub.2 CH(CH.sub.3).sub.2                                                                   118-120                                     22  Cl  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                            98-100                                     23  Cl  C(O)NHCH.sub.2 -cyclopropyl                                                                CH.sub.2 CH(CH.sub.3).sub.2                                                                   60-63                                       24  Cl  C(O)NH-cyclopropyl                                                                         CH.sub.2 CH(CH.sub.3).sub.2                                                                   78-80                                       25  Cl  CN          CHCH(CH.sub.3).sub.2                                                                          65-68                                       26  Cl  C(O)NHOCH.sub.3                                                                            CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                         27  Cl  C(O)N(CH.sub.3).sub.2                                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                         28  Cl  C(O)NCH.sub.3 (OCH.sub.3)                                                                  CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                         29  Cl                                                                                  ##STR190## CH.sub.2 CH(CH.sub.3).sub.2                                                                   50-53                                       30  Cl  CN          CH.sub.2 CH.sub.2 CH.sub.3                                                                    oil                                         31  Cl  CO.sub.2 H  CH.sub.2 CH.sub.2 CH.sub.3                                                                    90-93                                       32  Cl  CO.sub.2 H  CH.sub.2 -cyclopentyl                                                                         87-89                                       33  Cl  CO.sub.2 H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                           oil                                         34  Cl  CO.sub.2 H  CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          oil                                         35  Cl  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                    94-95                                       36  Cl  CN          CH.sub.2 (CH.sub.2).sub.4 CH.sub.3                                                            oil                                         37  Cl  C(O)NH.sub.2                                                                               CH.sub.2 (CH.sub.2).sub.4 CH.sub.3                                                            87-89                                       38  Cl  CN          CH.sub.2 (CH.sub.3).sub.3                                                                     42-45                                       39  Br  CN          CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          oil                                         40  Cl  CO.sub.2 H  C.sub.6 H.sub.5                                                                               183-185                                     41  Br  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          110-112                                     42  Cl  CHO         CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                         43  Br  CO.sub.2 H  CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          oil                                         45  Cl  C(O)NH.sub.2                                                                               CH.sub.2 C(CH.sub.3).sub.3                                                                    110-114                                     46  Cl  CNOCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                         47  Cl  CH.sub.2 OH CH.sub.2 CH(CH.sub.3).sub.2                                                                   oil                                         48  Cl  C(O)NH.sub.2                                                                               CHCH(CH.sub.3).sub.2                                                                          115-118                                     49  Cl  CN          CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             60-67                                       50  Cl  C(S)NH.sub.2                                                                               CH.sub.2 CH(CH.sub.3).sub.2                                                                   175-184                                     51  Cl  CN          CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2                                CH.sub.3       oil                                         52  Cl  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             138-144                                     53  Cl  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2                                CH.sub.3       80-84                                       54  Br  C(O)NH.sub.2                                                                               CH.sub.2 -cyclopentyl                                                                          97-105                                     55  Br  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                           111-114                                     56  Br  CN          t-butyl        47                                          57  Br  CN          CH.sub.2 -cyclopentyl                                                                         64-66                                       58  Br  CN          CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                           oil                                         59  Cl  CN          CH.sub.2 CH(CH.sub.3 ).sub.2                                                                  49-50                                       60  OCH.sub.3                                                                          CN          CH.sub.2 (CH.sub.3).sub.3                                  61  Cl  CO.sub.2 H  OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          95-98                                       62  Cl  CN          OC.sub.6 H.sub.5                                                                              39-41                                       63  Cl  CN          SC(CH.sub.3).sub.3                                                                            oil                                         64  Cl  CN          OCH.sub.2 CH(CH.sub.3).sub.2                                                                  oil                                         65  Cl  C(O)NH.sub.2                                                                               O(t-butyl)     118-119                                     66  Cl  C(O)NH.sub.2                                                                               OC.sub.6 H.sub.5                                                                              145-146                                     67  Cl  C(O)NH.sub.2                                                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                                  112-115                                     68  Cl  CN          CH.sub.2 OC.sub.6 H.sub.5                                                                     138-140                                     69  Cl  C(O)NH.sub.2                                                                               CH.sub.2 OC.sub.6 H.sub.5                                                                     156-148                                     70  Cl  C(O)NH.sub.2                                                                               S(t-butyl)     78-80                                       71  Br  C(O)NH.sub.2                                                                               CH.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                            68-70                                       72  Br  C N         CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2                                CH.sub.3       oil                                         73  Br  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2                                CH.sub.3       oil                                         74  Cl  C(O)NH.sub.2                                                                               2ClC.sub.6 H.sub.4                                                                            200-201                                     75  Cl  C(O)NH.sub.2                                                                               4ClC.sub.6 H.sub.4                                                                            215-216                                     76  Cl  CHC(CN).sub.2                                                                              CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          70-71                                       77  Cl  CHC(CN)C(O)NH.sub.2                                                                        CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          132-135                                     78  Cl  HCC(CN)CO.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          48-49                                       79  Cl  CHCHCO.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                          oil                                         80  Br  C(O)NH.sub.2                                                                               CH.sub.2 C(CH.sub.3).sub.3                                                                    81-82                                       81  Cl  C(O)NH.sub.2                                                                               CH.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                            81-82                                       82  Br  CN          CH.sub.2 C(CH.sub.3).sub.3                                                                    oil                                         83  Cl  CN          CH.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                            oil                                         98  Cl  CN          3BrC.sub.6 H.sub.4                                                                            138-139                                     99  Cl  C(O)NH.sub.2                                                                               3BrC.sub.6 H.sub.4                                                                            160-161                                     100 Cl  CN          CH.sub.2 OC.sub.6 H.sub.5                                                                     138-140                                     101 Cl  C(O)NH.sub.2                                                                               CH.sub.2OC.sub.6 H.sub.5                                                                      156-158                                     102 Cl  C(O)NH.sub.2                                                                               OCH.sub.2 CH(CH.sub.3).sub.2                                                                  112-115                                     103 Cl  CN          4FC.sub.6 H.sub.4                                                                             85-87                                       104 Cl  CN          2ClC.sub.6 H.sub.4                                                                            102-105                                     105 Cl  C(O)NH.sub.2                                                                               3ClC.sub.6 H.sub.4                                                                            145-148                                     106 Cl  CN          4ClC.sub.6 H.sub.4                                                                            155-156                                     107 Cl  C(O)NH.sub.2                                                                               4FC.sub.6 H.sub.4                                                                             185-186                                     108 Cl  CN          3ClC.sub.6 H.sub.4                                                                            108-110                                     109 Cl  C(O)NH.sub.2                                                                               SCH.sub.2 CH(CH.sub.3).sub.2                                                                   95-100                                     110 Cl  CO.sub.2 H  SCH.sub.2 CH(CH.sub.3).sub.2                                                                  oil                                         111 Br  CN          CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2                                CH.sub.3       oil                                         112 Br  C(O)NH.sub.2                                                                               CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2                                CH.sub.3       semisolid                                   114 Cl  CN          SCH.sub.2 CH(CH.sub.3).sub.2                                                                  oil                                         115 Cl  C(O)NH.sub.2                                                                               SC(CH.sub.3).sub.3                                                                            78-80                                       116 Cl  C(O)NH.sub.2                                                                               OC(CH.sub.3).sub.3                                                                            118-119                                     117 Cl  CN          SC(CH.sub.3).sub.3                                                                            oil                                         __________________________________________________________________________

                  TABLE 5                                                          ______________________________________                                          ##STR191##                                                                    CMPD   R.sup.1                                                                              R.sup.2      R.sup.3   mp (°C.)                            ______________________________________                                         84     Br    C(O)NH.sub.2 CH.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                       87                                         ______________________________________                                    

                  TABLE 6                                                          ______________________________________                                          ##STR192##                                                                    CMPD     R.sup.2                                                                              R.sup.2   R.sup.3   mp (°C.)                             ______________________________________                                         44       Cl    CN        CH.sub.2 CH(CH.sub.3).sub.2                                                              72-73                                       ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                         CMPD              SPECTRAL DATA                                                ______________________________________                                          2    NMR (CDCl.sub.3):                                                                          ppm δ 8.1 (d, 1H); 7.13(d, 1H); 3.94                                     (s, 3H); 2.69(d, 2H); 2.1(m, 1H); 0.947                                        (d, 6H)                                                            IR (Neat):  1740 cm.sup.-1 (C═O)                                      5    NMR (CDCl.sub.3):                                                                          ppm δ 7.7(d, 1H); 6.8(d, 1H); 4.0(s, 3H);                                2.6(d, 2H); 2.2(m, 1H); 0.949(d, 6H)                               IR (Neat):  2210 cm.sup.-1 (C.tbd.N)                                     10    NMR (CDCl.sub.3):                                                                          ppm δ 7.86(d, 1H); 7.3(m, 2H); 7.13                                      (d, 1H); 4.8(s, 2H)                                                IR (Neat):  2210 cm.sup.-1 (C.tbd.N)                                     19    NMR (CDCl.sub.3):                                                                          ppm δ 7.8(d, 1H); 7.2(d, 1H); 2.7(d, 2H);                                2.1(m, 1H); 0.95(d, 6H)                                            IR (Neat):  2220 cm.sup.-1 (C.tbd.N)                                     20    NMR (CDCl.sub.3):                                                                          ppm δ 7.9(d, 1H); 7.2(d, 1H); 2.8                                        (t, 2H); 1.7(m, 2H); 1.4(m, 2H); 1.0                                           (t, 3H)                                                            IR (Neat):  2220 cm.sup.-1 (C.tbd.N)                                     26    NMR (CDCl.sub.3):                                                                          ppm δ 9.1(s, 1H); 8.0(d, 1H); 7.1(d, 1H);                                3.9(s, 3H); 2.7(d, 2H); 2.1(m, 1H); 0.9                                        (d, 6H);                                                     27    NMR (CDCl.sub.3):                                                                          ppm δ 7.5(d, 1H); 7.1(d, 1H); 3.1(s, 3H);                                2.9(s, 3H); 2.6(d, 2H); 2.1(m, 1H); 0.95                                       (d, 6H)                                                            IR (Neat):  1650 cm.sup.-1 (C═O)                                     28    NMR (CDCl.sub.3):                                                                          ppm δ 7.6(d, 1H); 7.1(d, 1H); 3.5(s, 3H);                                3.3(s, 3H); 2.7(d, 2H); 2.1(m, 1H); 0.949                                      (d, 6H)                                                            IR (Neat):  1650 cm.sup.-1 (C═O)                                     30    NMR (CDCl.sub.3):                                                                          ppm δ 7.9(d, 1H); 7.2(d, 1H); 2.8(t, 2H);                                1.8(m, 2H); 1.0(t, 3H)                                             IR (Nujol): 2220 cm.sup.-1 (C.tbd.N)                                     33    NMR (CDCl.sub.3):                                                                          ppm δ 8.5(bs, 1H); 8.2(d, 1H); 7.2(d, 1H);                               2.8(t, 2H); 1.7(m, 2H); 1.4(m, 2H); 1.0                                        (t, 3H)                                                            IR (Neat):  1740 cm.sup.-1 (C═O)                                     34    NMR (CDCl.sub.3):                                                                          ppm δ 8.28(d, 1H); 7.23(d, 1H); 2.8                                      (m, 2H); 1.6(m, 2H); 1.2(m, 1H); 0.97                                          (d, 6H)                                                            IR (Neat):  1700 cm.sup.-1 ; (C═O)                                   36    NMR (CDCl.sub.3):                                                                          ppm δ 7.9(d, 1H); 7.2(d, 1H); 2.8(t, 2H);                                1.7(m, 2H); 1.3(m, 6H); 0.9(t, 3H)                                 IR (Neat):  2220 cm.sup.-1 (C.tbd.N)                                     39    NMR (CDCl.sub.3):                                                                          ppm δ 7.8(d, 1H); 7.2(d, 1H); 2.8(t, 2H);                                1.6(m, 3H); 0.9(d, 6H)                                             IR (Neat):  2220 cm.sup.-1 (C.tbd.N)                                     42    NMR (CDCl.sub.3):                                                                          ppm δ 10.5(s, 1H) ; 8.2(d, 1H) ; 7.2(d, 1H)                              2.72(d, 2H); 2.2(m, 1H); 0.96(d, 6H)                               IR (Neat):  2860, 1730 cm.sup.-1 (C═O)                               43    NMR (CDCl.sub.3):                                                                          ppm δ 8.21(d, 1H); 7.24(d, 1H); 2.8                                      (m, 2H); 1.6(m, 3H); 0.967(m, 6H)                                  IR (Neat):  2940, 1700 cm.sup.-1 (C═O)                               46    NMR (CDCl.sub.3):                                                                          ppm δ 8.4(s, 1H); 8.05(d, 1H); 7.0                                       (d, 1H); 3.99(s, 3H); 2.61(d, 2H); 2.2                                         (m, 1H); 0.945(d, 6H                                               IR (Neat):  1580, 1540 cm.sup.-1 (C.tbd.N)                               47    NMR (CDCl.sub.3):                                                                          ppm δ 7.8(d, 1H); 7.1(d, 1H); 4.7(d, 2H);                                2.6(d, 2H); 2.1(m, 1H); 0.9(d, 6H)                                 IR (Neat):  3300 cm.sup.-1 (OH);                                         51    NMR (CDCl.sub.3):                                                                          ppm δ 7.89(d, 1H); 7.2(d, 1H); 2.8                                       (m, 2H); 2.8-1.0(m, 7H); 0.943(m, 6H)                              IR (Neat):  2220 cm.sup.-1 (C.tbd.N)                                     58    NMR (CDCl.sub.3):                                                                          ppm δ 7.8(d, 1H); 7.3(d, 1H); 2.86                                       (m, 2H); 1.8(m, 2H); 1.4(m, 2H); 0.96                                          (m, 3H)                                                            IR (Neat):  2210 cm.sup.-1 (C.tbd.N)                                     64    NMR (CDCl.sub.3):                                                                          ppm δ 7.8(m, 1H); 7.0(m, 1H); 4.2(m, 2H);                                2.1(m, 1H); 1.0(m, 6H)+6-isomer                                    IR (Neat):  2220 cm.sup.-1 (C.tbd.N)                                     72    NMR (CDCl.sub.3):                                                                          ppm δ 7.8(d, 1H); 7.2(d, 1H); 2.8(m, 2H);                                1.8-1.1(m, 7H); 1.0-0.8(m, 6H)                                     IR (Neat):  2220 cm.sup.-1 (C.tbd.N)                                     73    NMR (CDCl.sub.3):                                                                          ppm δ 7.9(d, 1H); 7.2(d, 1H); 6.7(s, 1H);                                6.5(s, 1H); 2.8(m, 2H); 1.8-1.1(m, 7H);                                        1.0-0.8(m, 6H)                                                     IR (Nujol): 3360, 3180 cm.sup.-1 (NH.sub.2)1650 cm.sup.-1 (C═O)                        9                                                            79    NMR (CDCl.sub.3):                                                                          ppm δ 7.98(d, 1H); 7.81(d, 1H); 7.13(d,                                  1H); 6.41(d, 1H); 3.83(s, 3H); 2.78                                            (m, 2H); 1.61(m, 3H); 0.94(d, 6H)                                  IR (Neat):  1710 cm.sup.-1 (C═O)                                     82    NMR (CDCl.sub.3):                                                                          ppm δ 7.83(m, 1H); 7.21(m, 1H); 2.7                                      (s, 2H); 1.02(s, 9H)                                               IR (Nujol)  2210 cm.sup.-1 (C.tbd.N)                                     83    NMR (CDCl.sub.3):                                                                          ppm δ 7.89(d, 1H); 7.22(d, 1H); 2.84(m,                                  2H); 1.8(m, 2H); 1.35(m, 4H); 0.899                                            (m, 3H)                                                            IR (Neat):  2210 cm.sup.-1 (C.tbd.N)                                     110   NMR(CDCl.sub.3):                                                                           ppm δ 8.2(m, 1H); 7.2(m, 1H); 3.05                                       (m, 2H); 2.0(m, 1H); 1.09(d, 6H)                             111   NMR (CDCl.sub.3):                                                                          ppm δ 7.82(d, 1H); 7.2(d, 1H); 2.8                                       (m, 2H); 1.8-1.0(m, 5H); 0.866(m, 6H)                              IR (Neat):  2210 cm.sup.-1 (C.tbd.N)                                     112   NMR (CDCl.sub.3):                                                                          ppm δ 7.94(d, 1H); 7.21(d, 1H); 6.7(bs,                                  1H); 6.6(bs, 1H); 2.8(m, 2H); 1.8-1.2(m,                                       7H); 0.9(m, 6H)                                                    IR (Nujol): 3350 cm.sup.-1 (NH); 1650 cm.sup.-1 (C═O)                114   NMR (CDCl.sub.3):                                                                          ppm δ 7.6(d, 1H); 7.05(d, 1H); 3.1                                       (m, 2H); 2.0(m, 1H); 1.0(m, 6H)+                                               10% isomer                                                         IR (Neat):  2210 cm.sup.-1 (C.tbd.N)                                     117   NMR (CDCl.sub.3):                                                                          ppm δ 7.6(d, 1H) ; 7.0(d, 1H); 1.67                                      (s, 9H)                                                            IR (Neat):  2210 cm.sup.-1 (C.tbd.N)                                     ______________________________________                                    

The following are additional compounds tested in Tests E, F and G.

    ______________________________________                                               COMMON                                                                   CMPD  NAME        CHEMICAL NAME                                                ______________________________________                                         86    bensulfuron 2-[[[[[(4,6-dimethoxy-2-pyrimidinyl)-                              methyl      amino]methylcarbonyl]amino]-                                                   sulfonyl]methyl]benzoic acid, methyl                                           ester                                                        87    CGA142464   N-[2-(2-methoxyethoxyphenyl sulfonyl]-                                         N'-4,6-dimethoxy-1,3,5-triazin-2-yl                                            urea                                                         88    DPX A8947   N-[[(4,6-dimethoxypyrimidin-2-yl)-                                             amino]carbonyl)-1-methyl-4-(2-                                                 methyl-2H-tetrazol-5-yl)-1H-                                                   pyrazole-5-sulfonamide                                       89    mefenacet   2-(2-benzothiazolyloxy)-N-methyl-N-                                            phenyl acetamide                                             90    metsulfuron 2-[[[[(4-methoxy-6-methyl-1,3,5-                                   methyl      triazin-2-yl)amino]carbonyl]amino]-                                            sulfonyl]benzoic acid, methyl ester                          91    molinate    S-ethyl hexahydro-1H-azepin-1-carbo-                                           thioate                                                      92    pyrazosulfuron                                                                             ethyl 5-[[[[(4,6-dimethoxy-2-                                      ethyl       pyrimidinyl)amino]carbonyl]amino]-                                             sulfonyl]-1-methyl-1H-pyrazole-4-                                              carboxylate                                                  93    quinclorac  3,7-dichloro-8-quinolinecarboxylic                                             acid                                                         94    (unknown)   N-[[(4,6-dimethoxy-2-pyrimidinyl)-                                             amino]carbonyl]-3-methyl-5-(2,2,2-                                             trifluoroethoxy)-4-isothiazole-                                                sulfonamide                                                  95    TH-913      3-chloro-N-[[(4,6-dimethoxy-2-                                                 pyrimidinyl)amino]carbonyl]imidazo-                                            [1,2-a]pyridine-3-sulfonamide                                96    MON7200     S,S-dimethyl 2-(difluoromethyl)-4-(2-                                          methylpropyl)-6-(trifluoromethyl)-                                             3,5-pyridinecarbothioate                                     97    butachlor   N-(butoxymethyl)-2-chloro-N-(2,6-                                              diethylphenyl)acetamide                                      ______________________________________                                    

TEST A

Seeds of barnyardgrass (Echinochloa crus-galli), cheatgrass (Bromus secalinus), cocklebur (Xanthium pensylvanicum), crabgrass (Digitaria spp.), giant foxtail (Setaria faberii), morningglory (Ipomoea spp.), sorghum (Sorghum bicolor), velvetleaf (Abutlion theophrasti), and wild oat (Avena fatua) were planted into a sandy loam soil and treated preemergence with test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were also treated postemergence with test chemicals. Plants ranged in height from two to eighteen cm and were in the two to three leaf stage for the postemergence treatment. Treated plants and untreated controls were maintained in a greenhouse for approximately eleven days, after which all treated plants were compared to untreated controls and visually evaluated for injury. Plant response ratings, summarized in Table A, are based on a 0 to 10 scale where 0 is no effect and 10 is complete control. A dash (-) response means no test results.

                  TABLE A                                                          ______________________________________                                                          COMPOUND                                                      Rate (2000 g/ha)   59      60                                                  ______________________________________                                         POSTEMERGENCE                                                                  Barnyardgrass      10      0                                                   Cheatgrass         0       0                                                   Cocklebur          --      0                                                   Crabgrass          1       0                                                   Giant foxtail      0       0                                                   Morningglory       0       0                                                   Sorghum            0       0                                                   Velvetleaf         0       0                                                   Wild oat           0       0                                                   PREEMERGENCE                                                                   Barnyardgrass      9       0                                                   Cheatgrass         0       0                                                   Cocklebur          --      0                                                   Crabgrass          0       0                                                   Giant foxtail      0       0                                                   Morningglory       0       0                                                   Sorghum            0       0                                                   Velvetleaf         0       0                                                   Wild oat           0       0                                                   ______________________________________                                    

TEST B

Seeds of barley (Hordeum vulgate), barnyardgrass (Echinochloa crus-galli), bedstraw (Galium aparine), blackgrass (Alopecurus myosuroides), cheatgrass (Bromus secalinus), chickweed (Stellaria media), cocklebur (Xanthium pensylvanicum), corn (Zea mays), cotton (Gossypium hirsutum), crabgrass (Digitaria spp.), giant foxtail (Setaria faberii), lambsquarters (Chenopodium album), morningglory (Ipomoea hederacea), rape (Brassica napus), rice (Oryza sativa), sorghum (Sorghum bicolor), soybean (Glycine max), sugar beet (Beta vulgaris), velvetleaf (Abutilon theophrasti), wheat (Triticum aestivum), wild buckwheat (Polygonum convolvulus), and wild oat (Avena fatua) and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were also treated with postemergence applications of test chemicals. Plants ranged in height from two to eighteen cm (one to four leaf stage) for postemergence treatments. Treated plants and controls were maintained in a greenhouse for twelve to sixteen days, after which all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table B, are based on a scale of 0 to 10 where 0 is no effect and 10 is complete control. A dash (-) response means no test result.

                                      TABLE B                                      __________________________________________________________________________                COMPOUND                                                                       1 2 3 4 5 6 7  8 9 10                                                                               11                                                                               12 13                                                                               14                                                                               15                                                                               16                                                                               17 18                                                                               19                                                                               20                                                                               21                                                                               22 23                                                                               24                __________________________________________________________________________     Rate (2000 g/ha)                                                               POSTEMERGENCE                                                                  Barley     0 0 0 0 0 0 0  0 0 0 0    0 0 1 1 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Barnyardgrass                                                                             10                                                                               9 10                                                                               0 2 10                                                                               7  10                                                                               10                                                                               2 10   10                                                                               7 9 3 3  10      10                                                                             10                                                                             10                                                                             10 8 3                 Bedstraw   0 0 0 0 0 2 0  0 0 0 0    0 0 1 1 0  0       0                                                                              0                                                                              0                                                                              -- 0 0                 Blackgrass 0 --                                                                               0 0 0 1 0  0 0 0 0    0 0 1 1 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cheatgrass 0 0 0 0 0 0 0  0 0 0 0    0 0 1 1 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Chickweed  0 0 0 --                                                                               0 2 0  0 0 0 0    0 --                                                                               1 --                                                                               0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cocklebur  1 0 0 0 0 0 0  0 0 0 0    0 1 0 1 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Corn       0 0 0 0 0 0 0  0 0 0 0    0 0 1 1 0  1       1                                                                              0                                                                              0                                                                              0  0 0                 Cotton     2 0 0 0 0 0 1  0 0 0 0    0 1 0 1 0  7       0                                                                              2                                                                              0                                                                              4  0 0                 Crabgrass  0 0 0 0 0 0 0  0 0 0 0    0 2 1 1 0  1       5                                                                              0                                                                              0                                                                              1  3 3                 Giant foxtail                                                                             0 0 0 0 0 3 0  0 0 0 0    0 2 1 1 0  2       1                                                                              0                                                                              0                                                                              1  2 0                 Lambsquarters                                                                             0 --                                                                               --                                                                               --                                                                               0 2 0  0 1 0 0    0 0 1 1 0  1       0                                                                              0                                                                              0                                                                              0  0 1                 Morningglory                                                                              0 1 0 0 0 0 0  0 0 0 0    0 1 0 1 0  1       0                                                                              0                                                                              0                                                                              0  0 2                 Nutsedge   0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Rape       0 0 0 0 0 2 0  1 0 0 0    0 0 1 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Rice       0 0 0 0 0 0 0  2 0 0 0    0 0 0 0 0  5       2                                                                              0                                                                              0                                                                              2  0 0                 Sorghum    0 0 0 0 0 0 0  0 0 0 0    0 0 1 1 0  1       0                                                                              1                                                                              0                                                                              0  0 0                 Soybean    4 0 0 0 0 0 1  2 0 0 0    0 1 0 1 0  1       0                                                                              1                                                                              0                                                                              2  0 0                 Sugar beet 0 0 0 0 0 0 0  0 0 0 0    0 0 1 1 0  1       0                                                                              0                                                                              0                                                                              0  0 0                 Velvetleaf 0 0 3 3 0 0 0  0 0 0 0    0 1 0 1 0  2       6                                                                              0                                                                              0                                                                              0  0 0                 Wheat      0 0 0 0 0 0 0  0 0 0 0    0 0 1 1 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wild buckwheat                                                                            --                                                                               0 --                                                                               0 --                                                                               --                                                                               -- 0 0 0 0    --                                                                               0 1 1 -- 0       0                                                                              --                                                                             0                                                                              0  0 1                 Wild oat   0 0 0 0 0 2 0  0 0 0 0    0 0 1 1 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 PREEMERGENCE                                                                   Barley     0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Barnyardgrass                                                                             9 5 10                                                                               0 1 10                                                                               0  10                                                                               9 4 10   10                                                                               7 9 1 1  10      10                                                                             10                                                                             10                                                                             10 9 6                 Bedstraw   0 0 0 0 --                                                                               --                                                                               -- 0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Blackgrass 0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cheatgrass 0 0 0 0 2 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Chickweed  0 0 0 0 0 0 0  0 0 0 0    0 0 0 --                                                                               0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cocklebur  0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Corn       0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cotton     0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Crabgrass  1 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Giant foxtail                                                                             2 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Lambsquarters                                                                             0 0 0 0 0 0 0  0 3 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Morningglory                                                                              0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  1       0                                                                              0                                                                              0                                                                              0  0 0                 Nutsedge   0 4 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Rape       0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Rice       2 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  3       0                                                                              0                                                                              0                                                                              0  0 0                 Sorghum    0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Soybean    0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Sugar beet 0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Velvetleaf 0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wheat      0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wild buckwheat                                                                            0 --                                                                               0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wild oat   0 0 0 0 0 0 0  0 0 0 0    0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Rate (400 g/ha)                                                                POSTEMERGENCE                                                                  Barley     0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Barnyardgrass                                                                             9 3 10                                                                               0 0 10                                                                               1  10                                                                               9 2 10                                                                               10 10                                                                               2 10                                                                               1 1  9       10                                                                             10                                                                             10                                                                             10 3 2                 Bedstraw   0 0 0 0 0 2 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              --                                                                             0                                                                              0  0 0                 Blackgrass 0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 --                Cheatgrass 0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Chickweed  0 0 0 0 0 0 0  0 --                                                                               0 0 0  0 --                                                                               --                                                                               0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cocklebur  0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Corn       0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cotton     0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              1  0 0                 Crabgrass  0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Giant foxtail                                                                             0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  1       0                                                                              0                                                                              0                                                                              0  0 0                 Lambsquarters                                                                             0 --                                                                               0 --                                                                               0 0 0  0 0 0 0 0  0 0 --                                                                               0 0  0       0                                                                              0                                                                              0                                                                              0  0 --                Morningglory                                                                              0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Nutsedge   0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Rape       0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Pace       0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  1       0                                                                              0                                                                              0                                                                              0  0 0                 Sorghum    0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Soybean    0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              2  0 0                 Sugar beet 0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Velvetleaf 0 --                                                                               0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  --                                                                               0                 Wheat      0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wild buckwheat                                                                            --                                                                               0 0 0 --                                                                               --                                                                               -- 0 0 0 0 0  --                                                                               0 0 --                                                                               -- 0       0                                                                              0                                                                              0                                                                              0  0 0                 Wild oat   0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 PREEMERGENCE                                                                   Barley     0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Barnyardgrass                                                                             9 3 10                                                                               0 0 9 0  10                                                                               9 2 10                                                                               7  10                                                                               2 10                                                                               1 0  10      10                                                                             10                                                                             10                                                                             10 6 4                 Bedstraw   0 0 0 0 --                                                                               0 -- 0 0 0 --                                                                               0  --                                                                               0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Blackgrass 0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cheatgrass 0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Chickweed  0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cocklebur  0 0 0 0 0 0 0  --                                                                               0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Corn       0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Cotton     0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Crabgrass  0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Giant foxtail                                                                             0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Lambsquarters                                                                             0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              --                                                                             -- --                                                                               0                 Morningglory                                                                              0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Nutsedge   0 --                                                                               --                                                                               0 0 0 0  0 0 0 0 0  --                                                                               0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Rape       0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Pace       0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  1       0                                                                              0                                                                              0                                                                              0  0 0                 Sorghum    0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Soybean    0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Sugar beet 0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Velvetleaf 0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wheat      0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wild buckwheat                                                                            0 0 --                                                                               0 0 0 0  0 0 0 --                                                                               0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 Wild oat   0 0 0 0 0 0 0  0 0 0 0 0  0 0 0 0 0  0       0                                                                              0                                                                              0                                                                              0  0 0                 __________________________________________________________________________                COMPOUND                                                                       25                                                                               26                                                                               27                                                                               28 29                                                                               30                                                                               31                                                                               32 33                                                                               34                                                                               35                                                                               36 37                                                                               38                                                                               39                                                                               40 41                                                                               42                                                                               43                                                                               44 45                                                                               46                                                                               47                 __________________________________________________________________________     Rate (2000 g/ha)                                                               POSTEMERGENCE                                                                  Barley     0 0 0 2  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Barnyardgrass                                                                             4 9 2 4  9 3 0 8  3 7 5 2  10                                                                               10                                                                               10                                                                               5  10                                                                               3        10                                                                             5                                                                              10                                                                             4 6                  Bedstraw   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              2                                                                              1                                                                              0 0                  Blackgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cheatgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Chickweed  0 0 0 0  1 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              1                                                                              0                                                                              0 0                  Cocklebur  --                                                                               0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        4                                                                              3                                                                              0                                                                              0 0                  Corn       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              2                                                                              0                                                                              0 0                  Cotton     0 0 0 4  0 0 0 2  0 3 0 0  0 0 0 0  0 0        0                                                                              5                                                                              0                                                                              3 0                  Crabgrass  0 0 1 1  0 0 0 1  0 0 0 0  0 0 0 0  0 0        3                                                                              1                                                                              0                                                                              --                                                                               0                  Giant foxtail                                                                             0 0 1 1  0 0 0 1  2 2 0 0  0 0 0 0  0 0        2                                                                              2                                                                              0                                                                              0 0                  Lambsquarters                                                                             0 0 0 0  1 0 0 0  0 0 0 0  1 0 0 1  1 0        0                                                                              2                                                                              1                                                                              0 0                  Morningglory                                                                              0 0 0 0  0 0 0 0  2 0 0 0  0 0 0 0  0 0        1                                                                              1                                                                              0                                                                              2 0                  Nutsedge   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Rape       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              1                                                                              0                                                                              0 0                  Rice       0 0 2 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              1                                                                              0                                                                              0 0                  Sorghum    0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              1                                                                              0                                                                              0 0                  Soybean    0 0 0 2  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              2                                                                              0                                                                              0 0                  Sugar beet 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              2                                                                              0                                                                              0 0                  Velvetleaf 0 0 0 0  2 0 0 0  0 0 0 0  0 0 0 1  0 0        0                                                                              1                                                                              0                                                                              0 0                  Wheat      0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Wild buckwheat                                                                            0 0 0 0  --                                                                               0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              1                                                                              1                                                                              0                    Wild oat   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  PREEMERGENCE                                                                   Barley     0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Barnyardgrass                                                                             7 9 2 4  7 5 0 9  6 9 7 3  9 10                                                                               10                                                                               5  10                                                                               2        10                                                                             2                                                                              10                                                                             4 5                  Bedstraw   0 0 0 0  0 0 0 0  0 0 --                                                                               0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              4 0                  Blackgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cheatgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Chickweed  0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cocklebur  0 --                                                                               0 0  0 0 0 0  0 0 --                                                                               0  0 0 0 0  0 0        10                                                                             0                                                                              0                                                                              --                                                                               0                  Corn       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cotton     0 0 0 3  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Crabgrass  0 0 0 2  0 0 0 0  0 0 0 0  0 0 0 0  0 0        3                                                                              0                                                                              0                                                                              0 0                  Giant foxtail                                                                             0 0 0 2  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              0                                                                              0                                                                              0 0                  Lambsquarters                                                                             0 0 0 0  0 0 0 0  0 0 0 -- 0 0 0 0  0 0        --                                                                             0                                                                              0                                                                              0 0                  Morningglory                                                                              0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              0                                                                              0                                                                              0 0                  Nutsedge   0 --                                                                               0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        4                                                                              0                                                                              0                                                                              0 0                  Rape       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Rice       0 0 0 0  2 0 0 0  0 0 0 0  0 0 0 0  0 0        1                                                                              0                                                                              0                                                                              0 0                  Sorghum    0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Soybean    0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Sugar beet 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Velvetleaf 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              0                                                                              0                                                                              0 0                  Wheat      0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Wild buckwheat                                                                            0 0 0 -- 0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Wild oat   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Rate (400 g/ha)                                                                POSTEMERGENCE                                                                  Barley     0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Barnyardgrass                                                                             2 6 1 2  6 2 0 4  0 3 3 0  7 10                                                                               10                                                                               5  10                                                                               2        10                                                                             1                                                                              10                                                                             2 2                  Bedstraw   --                                                                               0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Blackgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cheatgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Chickweed  0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cocklebur  0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              1                                                                              0                                                                              0 0                  Corn       0 0 0 0  0 0 0 0  0 0 0 0  --                                                                               0 0 0  0 0        0                                                                              1                                                                              0                                                                              0 0                  Cotton     0 0 0 2  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              1                                                                              0                                                                              0 0                  Crabgrass  --                                                                               0 1 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              1                                                                              0                                                                              0 0                  Giant foxtail                                                                             0 0 1 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              1                                                                              0                                                                              0 0                  Lambsquarters                                                                             --                                                                               --                                                                               0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Morningglory                                                                              0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              1                                                                              0                                                                              0 0                  Nutsedge   0 --                                                                               0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Rape       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Rice       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              1                                                                              0                                                                              0 0                  Sorghum    0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        1                                                                              0                                                                              0                                                                              0 0                  Soybean    0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Sugar beet 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Velvetleaf 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              1                                                                              0                                                                              0 0                  Wheat      0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Wild buckwheat                                                                            0 0 0 0  0 0 0 0  0 --                                                                               0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Wild oat   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  PREEMERGENCE                                                                   Barley     0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Barnyardgrass                                                                             3 9 1 4  5 2 0 6  5 9 3 2  7 9 10                                                                               5  10                                                                               1        10                                                                             0                                                                              10                                                                             2 0                  Bedstraw   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              3 0                  Blackgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cheatgrass 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Chickweed  0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cocklebur  0 0 0 0  0 0 0 -- 0 0 0 0  0 0 0 0  0 0        10                                                                             0                                                                              0                                                                              0 0                  Corn       0 0 0 0  0 --                                                                               0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Cotton     0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        --                                                                             0                                                                              0                                                                              0 0                  Crabgrass  0 0 0 2  0 0 0 0  0 0 0 0  0 0 0 0  0 0        3                                                                              0                                                                              0                                                                              0 0                  Giant foxtail                                                                             0 0 0 2  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              0                                                                              0                                                                              0 0                  Lambsquarters                                                                             0 --                                                                               0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Morningglory                                                                              0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Nutsedge   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Rape       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Rice       0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Sorghum    0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Soybean    0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Sugar beet 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Velvetleaf 0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        2                                                                              0                                                                              0                                                                              0 0                  Wheat      0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Wild buckwheat                                                                            0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  Wild oat   0 0 0 0  0 0 0 0  0 0 0 0  0 0 0 0  0 0        0                                                                              0                                                                              0                                                                              0 0                  __________________________________________________________________________                                           COMPOUND                                                                       49                                                                               50                                                                               51 52                                                                               53                                                                               54 55                                                                               56                                                                               57 58                                                                               59                __________________________________________________________________________                                Rate (2000 g/ha)                                                               POSTEMERGENCE                                                                  Barley     0                      0                                            Barnyardgrass                                                                             7                      10                                           Bedstraw   0                      0                                            Blackgrass 0                      3                                            Cheatgrass 0                      0                                            Chickweed  0                      0                                            Cocklebur  0                      --                                           Corn       0                      0                                            Cotton     0                      0                                            Crabgrass  2                      2                                            Giant foxtail                                                                             1                      0                                            Lambsquarters                                                                             0                      --                                           Morningglory                                                                              0                      2                                            Nutsedge   0                      0                                            Rape       0                      0                                            Rice       0                      0                                            Sorghum    0                      0                                            Soybean    0                      0                                            Sugar beet 0                      0                                            Velvetleaf 3                      0                                            Wheat      0                      0                                            Wild buckwheat                                                                            0                      0                                            Wild oat   0                      0                                            PREEMERGENCE                                                                   Barley     0                      0                                            Barnyardgrass                                                                             6                      10                                           Bedstraw   0                      0                                            Blackgrass 0                      0                                            Cheatgrass 0                      0                                            Chickweed  0                      --                                           Cocklebur  --                     --                                           Corn       2                      0                                            Cotton     0                      0                                            Crabgrass  3                      0                                            Giant foxtail                                                                             2                      0                                            Lambsquarters                                                                             0                      0                                            Morningglory                                                                              0                      1                                            Nutsedge   0                      0                                            Rape       0                      0                                            Rice       1                      0                                            Sorghum    0                      0                                            Soybean    0                      0                                            Sugar beet 0                      0                                            Velvetleaf 0                      0                                            Wheat      0                      0                                            Wild buckwheat                                                                            0                      0                                            Wild oat   0                      0                                            Rate (400 g/ha)                                                                POSTEMERGENCE                                                                  Barley     0 0 0  0 0 0  0 0 0  0 0                                            Barnyardgrass                                                                             4 2 6  8 10                                                                               10 10                                                                               3 10 10                                                                               10                                           Bedstraw   0 0 0  0 0 0  0 0 0  0 0                                            Blackgrass 0 0 0  0 0 0  0 0 0  0 0                                            Cheatgrass 0 0 0  0 0 0  0 0 0  0 0                                            Chickweed  0 0 0  0 0 0  0 0 0  0 0                                            Cocklebur  0 0 0  0 0 0  0 0 0  0 --                                           Corn       0 0 0  0 0 0  0 0 0  0 0                                            Cotton     0 3 8  0 0 0  0 0 0  0 0                                            Crabgrass  0 0 0  0 0 0  0 0 0  0 0                                            Giant foxtail                                                                             0 0 0  0 0 0  0 0 0  0 0                                            Lambsquarters                                                                             0 0 0  0 0 0  0 0 0  0 0                                            Morningglory                                                                              0 0 0  0 0 0  0 0 0  0 0                                            Nutsedge   0 0 0  0 0 0  0 0 0  0 0                                            Rape       0 0 0  0 0 0  0 0 0  0 0                                            Rice       0 0 2  0 0 0  0 0 0  0 0                                            Sorghum    0 0 0  0 0 0  0 0 0  0 0                                            Soybean    0 2 0  0 0 0  0 0 0  0 0                                            Sugar beet 0 0 0  0 0 0  0 0 0  0 0                                            Velvetleaf 0 0 0  0 0 0  0 0 0  0 0                                            Wheat      0 0 0  0 0 0  0 0 0  0 0                                            Wild buckwheat                                                                            0 0 0  0 0 0  0 0 0  0 0                                            Wild oat   0 0 0  0 0 0  0 0 0  0 0                                            PREEMERGENCE                                                                   Barley     0 0 0  0 0 0  0 0 0  0 0                                            Barnyardgrass                                                                             4 1 8  3 10                                                                               10 10                                                                               4 10 10                                                                               9                                            Bedstraw   0 0 0  0 0 0  0 0 0  0 0                                            Blackgrass 0 0 0  0 0 0  0 0 0  0 0                                            Cheatgrass 0 0 0  0 0 0  0 0 0  0 0                                            Chickweed  0 0 0  --                                                                               0 0  0 0 0  0 9                                            Cocklebur  0 0 0  0 0 0  0 0 0  0 0                                            Corn       0 0 0  0 0 0  0 0 0  0 0                                            Cotton     0 0 0  0 0 0  0 0 0  0 0                                            Crabgrass  2 2 0  0 0 0  0 0 0  0 0                                            Giant foxtail                                                                             0 3 0  0 0 0  0 0 0  0 0                                            Lambsquarters                                                                             0 0 0  0 0 0  0 0 0  0 0                                            Morningglory                                                                              0 0 0  0 0 0  0 0 0  0 0                                            Nutsedge   0 0 0  0 0 0  0 0 0  0 0                                            Rape       0 0 0  0 0 0  0 0 0  0 0                                            Rice       0 0 1  0 0 0  0 0 0  0 0                                            Sorghum    0 0 0  0 0 0  0 0 0  0 0                                            Soybean    0 0 0  0 0 0  0 0 0  0 0                                            Sugar beet 0 0 0  0 0 0  0 0 0  0 0                                            Velvetleaf 0 0 0  0 0 0  0 0 0  0 0                                            Wheat      0 0 0  0 0 0  0 0 0  0 0                                            Wild buckwheat                                                                            0 0 0  0 0 0  0 0 0  0 0                                            Wild oat   0 0 0  0 0 0  0 0 0  0 0                 __________________________________________________________________________                                Rate (100 g/ha)                                                                POSTEMERGENCE                                                                  Barley       0 0  0 0 0  0 0 0  0                                              Barnyardgrass                                                                               2 4  5 7 10 10                                                                               2 9  10                                             Bedstraw     0 0  0 0 0  0 0 0  0                                              Blackgrass   0 0  0 0 0  0 0 0  0                                              Cheatgrass   0 0  0 0 0  0 0 0  0                                              Chickweed    0 0  0 0 0  0 0 0  0                                              Cocklebur    0 0  0 0 0  0 0 0  0                                              Corn         0 0  0 0 0  0 0 0  0                                              Cotton       2 6  0 0 0  0 0 0  0                                              Crabgrass    0 0  0 0 0  0 0 0  0                                              Giant foxtail                                                                               0 0  0 0 0  0 0 0  0                                              Lambsquarters                                                                               0 0  0 0 0  0 0 0  0                                              Morningglory 0 0  0 0 0  0 0 0  0                                              Nutsedge     0 0  0 0 0  0 0 0  0                                              Rape         0 0  0 0 0  0 0 0  0                                              Rice         0 0  0 0 0  0 0 0  0                                              Sorghum      0 0  0 0 0  0 0 0  0                                              Soybean      0 0  0 0 0  0 0 0  0                                              Sugar beet   0 0  0 0 0  0 0 0  0                                              Velvetleaf   0 0  0 0 0  0 0 0  0                                              Wheat        0 0  0 0 0  0 0 0  0                                              Wild buckwheat                                                                              0 0  0 0 0  0 0 0  0                                              Wild oat     0 0  0 0 0  0 0 0  0                                              PREEMERGENCE                                                                   Barley       0 0  0 0 0  0 0 0  0                                              Barnyardgrass                                                                               0 4  3 9 10 10                                                                               3 10 10                                             Bedstraw     0 0  0 0 0  0 0 0  0                                              Blackgrass   0 0  0 0 0  0 0 0  0                                              Cheatgrass   0 0  0 --                                                                               0  0 0 0  0                                              Chickweed    0 0  0 --                                                                               0  0 0 0  0                                              Cocklebur    0 0  0 0 0  0 0 0  0                                              Corn         0 0  0 0 0  0 0 0  0                                              Cotton       0 0  0 0 0  0 0 0  0                                              Crabgrass    0 0  0 0 0  0 0 0  0                                              Giant foxtail                                                                               0 0  0 0 0  0 0 0  0                                              Lambsquarters                                                                               --                                                                               -- 0 0 0  0 0 0  0                                              Morningglory 0 0  0 0 0  0 0 0  0                                              Nutsedge     0 0  0 0 0  0 0 0  0                                              Rape         0 0  0 0 0  0 --                                                                               0  0                                              Rice         0 0  0 0 0  0 0 0  0                                              Sorghum      0 0  0 0 0  0 0 0  0                                              Soybean      0 0  0 0 0  0 0 0  0                                              Sugar beet   0 0  0 0 -- 0 0 0  0                                              Velvetleaf   0 0  0 0 0  0 0 0  0                                              Wheat        0 0  0 0 0  0 0 0  0                                              Wild buckwheat                                                                              0 0  0 0 0  0 0 0  0                                              Wild oat     0 -- 0 0 0  0 0 0  0                   __________________________________________________________________________

TEST C

The test chemicals were formulated in a non-phytoxic solvent and applied to water that covered the soil surface (flood application). Seeds of barnyardgrass (Echinochloa crus-galli), rice (Oryza sativa), umbrella sedge (Cyperus difformis) and duck salad (Heteranthera limosa) were planted in silt loam soil in separate containers. Containers of duck salad and umbrella sedge were flooded with water 2.5 cm above the soil level immediately after planting and grown for fourteen days prior to treatment. The containers of barnyardgrass and rice were grown for ten days (barnyardgrass at 2 leaf stage) and flooded one day prior to treatment. Water depth was maintained at approximately 2.5 cm for the duration of the test.

All plant species were grown using normal greenhouse practices. Treated plants were compared to untreated controls and visually evaluated eleven to fifteen days after treatment. Plant response ratings, summarized in Table C, were recorded on a 0 to 10 scale where 0 is no effect and 10 is complete control. A dash (-) response means no test result.

                  TABLE C                                                          ______________________________________                                                     COMPOUND                                                                       1     3       21     43    59                                      ______________________________________                                         POSTEMERGENCE                                                                  Rate (1000 g/ha)                                                               Duck salad    0                          0                                     Barnyardgrass 10                         10                                    Rice Japonica 0                          1                                     Umbrella sedge                                                                               0                          0                                     Rate (500 g/ha)                                                                Duck salad    0       0       0          0                                     Barnyardgrass 10      10      10         10                                    Rice Japonica 0       0       0          0                                     Umbrella sedge                                                                               0       0       0          0                                     Rate (250 g/ha)                                                                Duck salad    0       0                  0                                     Barnyardgrass 9       10                 9                                     Price Japonica                                                                               0       0                  0                                     Umbrella sedge                                                                               0       0                  0                                     Rate (125 g/ha)                                                                Duck salad    0       0       0    --    0                                     Barnyardgrass 9       10      10   10    9                                     Rice Japonica 0       0       0    1     0                                     Umbrella sedge                                                                               0       0       0    --    0                                     Rate (62 g/ha)                                                                 Duck salad            0                  0                                     Barnyardgrass         10                 7                                     Rice Japonica         0                  0                                     Umbrella sedge        0                  0                                     Rate (31 g/ha)                                                                 Duck salad                    0    --                                          Barnyardgrass                 10   10                                          Price Japonica                0    0                                           Umbrella sedge                0    --                                          Rate (8 g/ha)                                                                  Duck salad                    0    --                                          Barnyardgrass                 10   8                                           Rice Japonica                 0    0                                           Umbrella sedge                0    --                                          Rate (2 g/ha)                                                                  Barnyardgrass                      5                                           Rice Japonica                      0                                           ______________________________________                                    

TEST D

Plastic pots were partially filled with silt loam soil. The soil was then flooded with water, Japonica rice (Oryza sativa) sprouted seeds and 1.5 leaf transplants were planted in the soil. Seeds of barnyardgrass (Echinochloa crus-galli) were planted in saturated soil and plants grown to the 1 leaf, 2 leaf and 3 leaf stages for testing. At testing, the water level for all plantings was raised to 2 cm above the soil surface. Cal. Watergrass (E. oryzoides) was also planted. Chemical treatments were formulated in a non-phytotoxic solvent and applied directly to the paddy water. Treated plants and controls were maintained in a greenhouse for approximately 21 days, after which all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table D are reported on a 0 to 10 scale where 0 is no effect and 10 is complete control. A dash (-) response means no test result.

                                      TABLE D                                      __________________________________________________________________________              COMPOUND                                                                       1 3 13                                                                               37                                                                               41                                                                               43                                                                               45                                                                               53                                                                               54                                                                               55                                                                               57                                                                               58                                                                               59                                                                               65                                                                               66                                                                               80                                                                               81                                    __________________________________________________________________________     PADDY                                                                          Rate (1000 g/ha)                                                               1-LF B.Y. Grass                                                                         --                                                                               --                                                                               --                  10                                            2-LF B.Y. Grass                                                                         9 10                                                                               10                  10                                            3-Lf B.Y. Grass                                                                         9 10                                                                               10                  10                                            Jap Direct Seed                                                                         0 1 0                   0                                             Jap Rice Eff                                                                            0 0 0                   0                                             Rate (500 g/ha)                                                                1-LF B.Y. Grass                                                                         --                                                                               --                                                                               --                  10                                            2-LF B.Y. Grass                                                                         9 10                                                                               10                  10                                            3-Lf B.Y. Grass                                                                         9 10                                                                               10                  10                                            Jap Direct Seed                                                                         0 0 0                   0                                             Jap Rice Eff                                                                            0 0 0                   0                                             Rate (250 g/ha)                                                                1-LF B.Y. Grass                                                                         --                                                                               --                                                                               --                  10                                            2-LF B.Y. Grass                                                                         9 10                                                                               10                  10                                            3-Lf B.Y. Grass                                                                         8 10                                                                               10                  10                                            Jap Direct Seed                                                                         0 0 1                   0                                             Jap Rice Eff                                                                            0 0 0                   0                                             Rate (125 g/ha)                                                                1-LF B.Y. Grass                                                                         --                                                                               --                                                                               --                  10                                            2-LF B.Y. Grass                                                                         8 10                                                                               10                  10                                            3-Lf B.Y. Grass                                                                         7 10                                                                               10                  10                                            Jap Direct Seed                                                                         0 0 1                   0                                             Jap Rice Eff                                                                            0 1 0                   0                                             Rate (64 g/ha)                                                                 1-LF B.Y. Grass                                                                         --                                                                               --                                                                               --  --    --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               9 --                                                                               --                                                                               --                                                                               --                                    2-LF B.Y. Grass                                                                         7 10                                                                               10  --    --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               10                                                                               --                                                                               --                                                                               --                                                                               --                                    3-LF Watergrass                                                                         --                                                                               --                                                                               --  9     8 7 8 9 9 --                                                                               0 0 8 8                                     3-Lf B.Y. Grass                                                                         6 10                                                                               10  10    10                                                                               10                                                                               10                                                                               10                                                                               10                                                                               10                                                                               0 0 10                                                                               10                                    Jap Direct Seed                                                                         0 1 1   0     0 0 0 0 0 0 0 1 0 0                                     Jap Rice Eff                                                                            0 0 0   --    --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               --                                    Rate (32 g/ha)                                                                 2-LF B.Y. Grass                                                                           9 10                                                                               --                                                                               10                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               9 --                                                                               --                                                                               --                                                                               --                                    3-LF Watergrass                                                                           --                                                                               --                                                                               0 9 5 7 5 6 8 8 8 --                                                                               0 0 6 7                                     3-Lf B.Y. Grass                                                                           10                                                                               10                                                                               5 10                                                                               10                                                                               10                                                                               10                                                                               10                                                                               10                                                                               10                                                                               10                                                                               10                                                                               0 0 9 10                                    Jap Direct Seed                                                                           0 1 0 5 0 0 0 0 0 0 0 0 0 0 0 0                                     Jap Rice Eff                                                                              0 1 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               --                                    Rate (16 g/ha)                                                                 2-LF B.Y. Grass                                                                           9 10                                                                               --                                                                               10                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               9 --                                                                               --                                                                               --                                                                               --                                    3-LF Watergrass                                                                           --                                                                               --                                                                               0 8 3 4 3 5 8 7 7 --                                                                               0 0 8 6                                     3-Lf B.Y. Grass                                                                           9 10                                                                               3 10                                                                               10                                                                               10                                                                               7 10                                                                               10                                                                               8 10                                                                               10                                                                               0 0 10                                                                               9                                     Jap Direct Seed                                                                           0 1 0 5 0 0 0 0 0 0 0 0 0 0 0 0                                     Jap Price Eff                                                                             0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               --                                    Rate (8 g/ha)                                                                  2-LF B.Y. Grass                                                                           8 10                                                                               --                                                                               10                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               9 --                                                                               --                                                                               --                                                                               --                                    3-LF Watergrass                                                                           --                                                                               --                                                                               0 9 1 4 1 6 7 6 6 --                                                                               0 0 8 2                                     3-Lf B.Y. Grass                                                                           8 9 1 10                                                                               9 10                                                                               6 10                                                                               10                                                                               9 9 9 0 0 10                                                                               9                                     Jap Direct Seed                                                                           0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0                                     Jap Rice Eff                                                                              0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               --                                    Rate (4 g/ha)                                                                  2-LF B.Y. Grass                                                                           6 10                                                                               --                                                                               10                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               9 --                                                                               --                                                                               --                                                                               --                                    3-LF Watergrass                                                                           --                                                                               --                                                                               0 8 1 3 1 5 4 3 4 --                                                                               0 0 6 1                                     3-Lf B.Y. Grass                                                                           5 9 3 10                                                                               6 9 3 10                                                                               10                                                                               4 7 9 0 0 10                                                                               5                                     Jap Direct Seed                                                                           0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0                                     Jap Rice Eff                                                                              0 0 0 0 0 0 --                                                                               --                                                                               --                                                                               --                                                                               --                                                                               0 --                                                                               --                                                                               --                                                                               --                                    Rate (2 g/ha)                                                                  2-LF B.Y. Grass                                                                           0 --                                                                               --                                                                               10                                                                               --                                                                               --                                                        3-LF Watergrass                                                                           --                                                                               --                                                                               0 5 1 3                                                         3-Lf B.Y. Grass                                                                           4 4 4 10                                                                               3 9                                                         Jap Direct Seed                                                                           0 0 0 0 0 0                                                         Jap Face Eff                                                                              0 0 0 0 0 0                                                         __________________________________________________________________________

TESTS E, F AND G (MIXTURES)

Plastic pots were partially filled with silt loam soil. The soil was then flooded with water, Japonica rice (Oryza sativa) sprouted seeds and 1.5 leaf transplants were planted in the soil. Seeds of barnyardgrass (Echinochloa crus-galli) were planted in saturated soil and plants grown to the 1 leaf, 2 leaf and 3 leaf (31f) stages for testing. At testing, the water level for all plantings was raised to 2 cm above the soil surface. Chemical treatments were formulated in a non-phytotoxic solvent and applied directly to the paddy water. Treated plants and controls were maintained in a greenhouse for approximately 21 days, after which all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table E are reported on a 0 to 100 scale where 0 is no effect and 100 is complete control. A dash (-) response means no test result.

Numbers in parenthesis are the predicted activity of mixture by Colby equation

    A(1,2)=A(1)+A(2)-A(1) X A(2)/100

where A(1) and A(2) are activity of compound "1" and "2", respectively; A(1,2) is the predicted activity for mixture containing "1" and "2".

TEST E

                  TABLE E1                                                         ______________________________________                                         Compounds 41, 89, 88, and 86 on Cal. Watergrass (E. oryzoides)                 in soil from Japan (Toride Lt Clay) at the 31f stage.                          Compound No.  Rate g/ha       % Control                                        ______________________________________                                         Untreated Check                                                                              0               0                                                89            200             55                                               88 + 86       9 + 30          75                                               41            64              95                                               41            125             85                                               41            250             90                                               89 + 41       200 + 64        95 (98)                                          89 + 41       200 + 125       95 (93)                                          89 + 88 + 86 + 41                                                                            200 + 9 + 30 + 64                                                                              98 (99)                                          89 + 88 + 86 + 41                                                                            200 + 9 + 30 + 125                                                                             100 (99)                                         ______________________________________                                    

                  TABLE E2                                                         ______________________________________                                         Compounds 41, 91, and 86 on Cal. Watergrass (E. oryzoides)                     in soil from Japan (Toride Lt Clay) at the 31f stage.                          Compound No.   Rate g/ha     % Control                                         ______________________________________                                         Untreated Check                                                                               0             0                                                 91             1200          25                                                86             50            35                                                41             64            95                                                41             125           85                                                41             250           90                                                91 + 86        1200 + 50     55 (51)                                           91 + 86 + 41   1200 + 50 + 64                                                                               85 (98)                                           ______________________________________                                    

                  TABLE E3                                                         ______________________________________                                         Compounds 41 and 92 with Cal. Watergrass (E. oryzoides)                        in soil from Japan (Toride Lt Clay) at the 31f stage.                          Compound No.    Rate g/ha    % Control                                         ______________________________________                                         Untreated Check 0            0                                                 92              20           50                                                41              64           95                                                41              125          85                                                41              250          90                                                92 + 41         20 + 64      98 (98)                                           92 + 41         20 + 125     95 (93)                                           92 + 41         20 + 250     95 (95)                                           ______________________________________                                    

                  TABLE E4                                                         ______________________________________                                         Compounds 41, 88, and 90 with Cal. Watergrass (E. oryzoides)                   in soil from Japan (Toride Lt Clay) at the 31f stage.                          Compound No.    Rate g/ha    % Control                                         ______________________________________                                         Untreated Check 0            0                                                 88 + 90         9 + 4        60                                                41              64           95                                                41              125          85                                                41              250          90                                                88 + 90 + 41    9 + 4 + 64   90 (98)                                           88 + 90 + 41    9 + 4 + 125  95 (94)                                           88 + 90 + 41    9 + 4 + 250  100 (96)                                          ______________________________________                                    

                  TABLE E5                                                         ______________________________________                                         Compounds 41 and 86 with Cal. Watergrass (E. oryzoides)                        in soil from Japan (Toride Lt Clay) at the 31f stage.                          Compound No.    Rate g/ha    % Control                                         ______________________________________                                         Untreated Check 0            0                                                 86              50           35                                                41              64           95                                                41              125          85                                                41              250          90                                                86 + 41         50 + 64      85 (97)                                           86 + 41         50 + 125     95 (90)                                           86 + 41         50 + 250     90 (94)                                           ______________________________________                                    

                  TABLE F1                                                         ______________________________________                                         Compounds 41, 88, 86, and 89 with Cal. Watergrass                              (E. oryzoides) in Tama soil at the 31f stage.                                  Compound No.  Rate g/ha       % Control                                        ______________________________________                                         Untreated Check                                                                              0               0                                                89            300             20                                               88 + 86       9 + 30          45                                               41            64              75                                               41            250             75                                               89 + 88 + 86  300 + 9 + 30    45 (56)                                          89 + 88 + 86 + 41                                                                            300 + 9 + 30 + 64                                                                              98 (86)                                          89 + 88 + 86 + 41                                                                            300 + 9 + 30 + 250                                                                             95 (86)                                          ______________________________________                                    

                  TABLE F2                                                         ______________________________________                                         Compounds 41, 89, and 87 with Cal. Watergrass                                  (E. oryzoides) in Tama soil at the 31f stage.                                  Compound No.   Rate g/ha     % Control                                         ______________________________________                                         Untreated Check                                                                               0             0                                                 89             300           20                                                87             40            10                                                41             64            75                                                41             250           75                                                89 + 87        300 + 40      20 (28)                                           89 + 87 + 41   300 + 40 + 64 90 (80)                                           89 + 87 + 41   300 + 40 + 250                                                                               80 (80)                                           ______________________________________                                    

                  TABLE F3                                                         ______________________________________                                         Compounds 41, 89, and 95 with Cal. Watergrass                                  (E. oryzoides) in Tama soil at the 31f stage.                                  Compound No.   Rate g/ha     % Control                                         ______________________________________                                         Untreated Check                                                                               0             0                                                 89             300           20                                                95             90            10                                                41             64            75                                                41             250           75                                                89 + 95        300 + 90      40 (28)                                           89 + 95 + 41   300 + 90 + 64 98 (85)                                           89 + 95 + 41   300 + 90 + 250                                                                               90 (85)                                           ______________________________________                                    

                  TABLE F4                                                         ______________________________________                                         Compounds 41, 88, and 86 with Cal. Watergrass                                  (E. oryzoides) in Tama soil at the 31f stage.                                  Compound No.    Rate g/ha    % Control                                         ______________________________________                                         Untreated Check 0            0                                                 88 + 86         9 + 30       45                                                41              64           75                                                41              250          75                                                88 + 86 + 41    9 + 30 + 64  85 (78)                                           88 + 86 + 41    9 + 30 + 250 90 (86)                                           ______________________________________                                    

                  TABLE F5                                                         ______________________________________                                         Compounds 41 and 87 with Cal. Watergrass                                       (E. oryzoides) in Tama soil at the 31f stage.                                  Compound No.    Rate g/ha    % Control                                         ______________________________________                                         Untreated Check 0            0                                                 87              40           10                                                41              64           75                                                41              250          75                                                87 + 41         40 + 64      85 (78)                                           87 + 41         40 + 250     85 (78)                                           ______________________________________                                    

                  TABLE F6                                                         ______________________________________                                         Compounds 41 and 95 with Cal. Watergrass                                       (E. oryzoides) in Tama soil at the 31f stage.                                  Compound No.    Rate g/ha    % Control                                         ______________________________________                                         Untreated Check 0            0                                                 95              90           30                                                41              64           75                                                41              250          75                                                95 + 41         90 + 64      85 (82)                                           95 + 41         90 + 250     100 (82)                                          ______________________________________                                    

TEST G

Japonica Rice (M202) direct seeded into the pots and treated at 2 leaf stage. California Watergrass was grown to the 3 leaf stage (LW3) prior to treatment. Results of percent injury were done by visual ratings 17 days after treatment. Predicted herbicidal activity due to additive ffect, calculated based on Colby's equation, was also included in the Tables (numbers in parentheses).

                  TABLE G1                                                         ______________________________________                                         Compounds 93, 41, 88, and 86                                                                                      % Control                                   Compound No.                                                                               Rate g/ha      Rice    LW3                                         ______________________________________                                         88 + 86     9 + 30         25      55                                          41          64             0       70                                          41          250            0       80                                          93          150            10      15                                          93 + 41     150 + 64       10      70 (74.5)                                   93 + 41     150 + 250      15      75 (83.0)                                   93 + 41 + 88 + 86                                                                          150 + 64 + 6 + 30                                                                             20      80                                          93 + 41 + 88 + 86                                                                          150 + 250 + 6 + 30                                                                            25      80                                          ______________________________________                                    

                  TABLE G2                                                         ______________________________________                                         Compounds 93, 13, 88, and 86                                                                                      % Control                                   Compound No.                                                                               Rate g/ha      Rice    LW3                                         ______________________________________                                         93          150            10      15                                          13          64             0       80                                          13          250            0       75                                          93 + 13     150 + 64       0       75 (83.0)                                   93 + 13     150 + 250      0       70 (78.8)                                   93 + 13 + 88 + 86                                                                          150 + 64 + 6 + 30                                                                             25      85                                          93 + 13 + 88 + 86                                                                          150 + 250 + 6 + 30                                                                            25      80                                          93 + 41 + 88 + 86                                                                          150 + 250 + 6 + 30                                                                            25      80                                          ______________________________________                                    

                  TABLE G3                                                         ______________________________________                                         Compounds 94, 41, and 13                                                                                        % Control                                     Compound No. Rate g/ha   Rice    LW3                                           ______________________________________                                         88 + 86      9 + 30      25      55                                            41           64          0       70                                            41           250         0       80                                            13           64          0       80                                            13           250         0       75                                            94           45          25      50                                            94 + 41      45 + 64     30      85 (82.5)                                     94 + 41      45 + 250    25      85 (90.0)                                     94 + 41      45 + 64     30      85 (90.0)                                     94 + 41      45 + 250    25      80 (87.5)                                     ______________________________________                                    

                  TABLE G4                                                         ______________________________________                                         Compounds 96, 41, 88, and 86                                                                                      % Control                                   Compound No. Rate g/ha     Rice    LW3                                         ______________________________________                                         41           9 + 30        25      55                                          41           64            0       70                                          41           250           0       80                                          96           60            10      30                                          96 + 41      60 + 64       15      90 (79)                                     96 + 41      60 + 250      10      85 (86)                                     96 + 41 + 88 + 86                                                                           60 + 64 + 9 + 30                                                                             25      85                                          96 + 41 + 88 + 86                                                                           60 + 250 + 9 + 30                                                                            20      85                                          ______________________________________                                    

                  TABLE G5                                                         ______________________________________                                         Compounds 96, 13, 88, and 86                                                                                      % Control                                   Compound No. Rate g/ha     Rice    LW3                                         ______________________________________                                         88 + 86      9 + 30        25      55                                          96           60            10      30                                          13           64            0       80                                          13           250           0       75                                          96 + 13      60 + 64       0       85 (86)                                     96 + 13      60 + 250      10      90 (82.5)                                   96 + 13 + 88 + 86                                                                           60 + 64 + 9 + 30                                                                             25      80                                          96 + 13 + 88 + 86                                                                           60 + 250 + 9 + 30                                                                            25      90                                          ______________________________________                                    

                  TABLE G6                                                         ______________________________________                                         Compounds 97, 41, 88, and 86                                                                                      % Control                                   Compound No.                                                                               Rate g/ha      Rice    LW3                                         ______________________________________                                         88 + 86     9 + 30         25      55                                          41          64             0       70                                          41          250            0       80                                          97          250            0       35                                          97 + 41     250 + 64       0       98 (82)                                     97 + 41     250 + 250      0       95 (83.8)                                   97 + 41 + 88 + 86                                                                          250 + 64 + 9 + 30                                                                             20      80                                          97 + 41 + 88 + 86                                                                          250 + 250 + 9 + 30                                                                            25      80                                          ______________________________________                                    

                  TABLE G7                                                         ______________________________________                                         Compounds 97, 13, 88, and 86                                                                                      % Control                                   Compound No. Rate g/ha     Rice    LW3                                         ______________________________________                                         97           250           0       35                                          88 + 86      9 + 30        25      55                                          13           64            0       80                                          13           250           0       75                                          97 + 13      250 + 64      0       90 (87)                                     97 + 13      250 + 250     0       95                                          97 + 13 + 88 + 86                                                                           250 + 64 + 9 + 30                                                                            20      80                                          97 + 13 + 88 + 86                                                                           250 + 64 + 9 + 30                                                                            20      80                                          ______________________________________                                     

What is claimed is:
 1. Agriculturally suitable compositions for controlling the growth of undesired vegetation in a crop comprising an effective amount of a compound of Formula I ##STR193## wherein R¹ is Cl, Br, I, OCH₃, OCHF₂ or OCF₃ ;R² is CN, CO₂ R⁴, CHO, C(X)NR¹⁷ R¹⁸, C(S)OR⁶, C.tbd.CH, CHR¹⁹ OR²⁰, CH═NOR⁷ or CH═CR²¹ R²² ; R³ is n-propyl; C₄ -C₁₀ alkyl; n-propyl or C₄ -C₇ alkyl substituted with one or more halogen, OR⁸, SR⁹ or NR¹⁰ R¹¹ ; C₁ -C₃ alkyl substituted with OR¹⁶, CO₂ (C₁ -C₂ alkyl) or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; C₃ -C₆ cycloalkyl; CH₂ (C₃ -C₆ cycloalkyl); phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; C₂ -C₆ alkenyl optionally substituted with one or more halogen or CO₂ (C₁ -C₂ alkyl); OR¹² ; SR¹³ ; or NR¹⁴ R¹⁵ ; R⁴ is H, C₁ -C₂ alkyl, ##STR194## R⁶, R⁷, R⁸, R⁹, R¹⁰ and R¹¹ are independently H or C₁ -C₂ alkyl; R¹² and R¹³ are independently C₂ -C₁₀ alkyl optionally substituted with one or more halogen, OR⁸, SR⁹ or NR¹⁰ R¹¹ ; phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; or benzyl; R¹⁴ and R¹⁵ are independently H or C₁ -C₂ alkyl, or may be taken together as --(CH₂)₄ --, --(CH₂)₅ -- or --(CH₂ CH₂ OCH₂ CH₂)--; R¹⁶ is H, C₁ -C₈ alkyl; benzyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; R¹⁷ is H, C₁ -C₂ alkyl or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; R¹⁸ is H, C₁ -C₂ alkyl, C₃ -C₆ cycloalkyl, CH₂ (C₃ -C₆ cycloalkyl), O(C₁ -C₄ alkyl), O-allyl or may be taken together with R¹⁷ as --(CH₂)₄ --, --(CH₂)₅ -- or --(CH₂ CH₂ OCH₂ CH₂)--; R¹⁹ is H or C₁ -C₂ alkyl; R²⁰ is H or C(O)CH₃ ; R²¹ and R²² are independently H, CN, CO₂ R⁴, C(X)NR¹⁷ R¹⁸ or halogen; X is O or S;or their N-oxides or agriculturally suitable salts thereof provided that when R¹ is Cl, Br or I, and R² is CN, CO₂ R⁴ or C(O)NR¹⁷ R¹⁸, then R³ is other than optionally substituted 5-phenyl and at least one of the following: surfactant, solid, or liquid diluent.
 2. The compositions of claim 1 whereinR¹ is Cl, Br, I or OCH₃ ; R² is CN, CO₂ R⁴, CHO, C(X)NH₂, C(X)NH(C₁ -C₂ alkyl), C(X)N(C₁ -C₂ alkyl)₂, C(S)OR⁶ or C.tbd.CH; R³ is n-propyl, C₄ -C₆ alkyl, C₃ -C₆ cycloalkyl or phenyl; R⁴ is H or C₁ -C₂ alkyl; and R⁶ is C₁ -C₂ alkyl.
 3. The compositions of claim 1 whereinR¹ is Cl, Br or I; R² is CN, CO₂ H, CO₂ CH₃, CO₂ CH₂ CH₃, CHO, C(O)NH₂, C(O)NHCH₃, C(O)N(CH₃)₂, CH₂ OH or CH═NOR⁷ ; R³ is n-propyl; C₄ -C₇ alkyl; C₂ alkyl substituted with phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen; CH₂ (C₃ -C₆ cycloalkyl); or phenyl optionally substituted with one or more CH₃, CF₃, OCH₃, SCH₃ or halogen.
 4. The compositions of claim 3 whereinR¹ is Cl or Br; R² is CN, CO₂ H or C(O)NH₂ ; R³ is C₄ -C₇ alkyl or CH₂ (C₃ -C₆ cycloalkyl).
 5. The compositions of of claim 4 wherein R³ is substituted at the 6-pyridine position.
 6. The composition of claim 5 wherein the compounds are 2-bromo-6-(3-methylbutyl)-3-pyridinecarboxamide or 2-chloro-6-(3-methylbutyl)-3-pyridinecarboxamide.
 7. A method for controlling the growth of barnyardgrass or California watergrass in a crop by applying to the locus of the crop to be protected an effective amount of a composition of any one of claims 1-6.
 8. The compositions of claim 1 wherein there is in combination with the compound of Formula I when R¹ is Br or Cl, R² is C(O)NH₂ and R³ is CH₂ CH₂ CH(CH₃)₂, one or more herbicidal compound selected from the group consisting of bensulfuron methyl; mefenacet; metsulfuron methyl; pyrazosulfuron ethyl; butachlor; N-[2-(2-methoxyethoxyphenylsulfonyl]-N¹ -4,6-dimethoxy-1,3,5-triazin-2-yl urea; N-[[(4,6-dimethoxypyrimidin-2-yl)amino]carbonyl]-1-methyl-4-(2-methyl-2H-tetrazol-5-yl)-1H-pyrazole-5-sulfonamide; S,S-dimethyl 2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridinecarbothiate; and 3-chloro-N[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]imidazo[1,2-a]pyridine-3-sulfonamide.
 9. The composition of claim 8 wherein the herbicidal compound is selected from butachlor and 3-chloro-N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]imidazo-[1,2-a]pyridine-3-sulfonamide.
 10. The composition of claim 8 wherein R¹ is Br and the herbicidal compound is mefenacet. 